Nutritional status and metabolic disorders in HIV-exposed uninfected prepubertal children

Nutritional status and metabolic disorders in HIV-exposed uninfected prepubertal children

Author Claudio, Cristiane Chiantelli Autor UNIFESP Google Scholar
Patin, Rose Vega Autor UNIFESP Google Scholar
Palchetti, Cecilia Zanin Autor UNIFESP Google Scholar
Machado, Daisy Maria Autor UNIFESP Google Scholar
Menezes Succi, Regina Celia de Autor UNIFESP Google Scholar
Oliveira, Fernanda Luisa Ceragioli Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the objective of the study was to assess the nutritional status and metabolic alterations in HIV-exposed uninfected (HIVe) children compared with HIV-unexposed (HIVn) children.Methods: A cross-sectional study was carried out with 76 children distributed into two groups: HIVe (n = 31) and HIVn (n = 45). Biochemical data (hematologic test, lipid profile, insulin resistance, hepatic profile, and C-reactive protein) were evaluated. Anthropometric parameters and body composition analyses were performed.Results: the groups were similar regarding body mass index-for-age z-scores (P = 0.297) and height-for-age z-scores (P = 0.666). HIVe had a higher dyslipidemia prevalence (38.7% versus 11.1%; P = 0.010), altered total cholesterol (TC) values (19.4% versus 2.2%; P = 0.016) higher LDL-C mean levels (97.8 mg/dl versus 86 mg/dl; P = 0.028), borderline low-density lipoprotein cholesterol (LDL-C) (40% versus 14%; P = 0.011) and TC (41.9% versus 20%; P = 0.038) compared with HIVn.Conclusion: Despite the similar nutritional status between groups, our data clearly demonstrated a higher prevalence of dyslipidemia, altered TC, higher LDL-C levels and also LDL-C and TC borderline values in HIVe children. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Dyslipidemia
HIV
Child
Prophylaxis
Nutrition
Language English
Date 2013-07-01
Published in Nutrition. New York: Elsevier B.V., v. 29, n. 7-8, p. 1020-1023, 2013.
ISSN 0899-9007 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1020-1023
Origin http://dx.doi.org/10.1016/j.nut.2013.01.019
Access rights Closed access
Type Article
Web of Science ID WOS:000321029700016
URI http://repositorio.unifesp.br/handle/11600/36497

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