Activation and involvement of the lateral-posterior nucleus of the thalamus after a single generalized tonic-clonic seizure

Activation and involvement of the lateral-posterior nucleus of the thalamus after a single generalized tonic-clonic seizure

Author Sonoda, Eliza Yumi de Freitas Autor UNIFESP Google Scholar
Cysneiros, Roberta Monterazzo Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Presbiteriana Mackenzie
Abstract The lateral-posterior thalamic nuclei (LP) have been shown to play an important role in controlling epileptic activity. in addition, thalamic atrophy and neuronal loss have been observed in epilepsy. the objective of this study was to investigate whether lateral-posterior neuronal activation may be observed shortly after a single generalized seizure in rats submitted to the pilocarpine model of epilepsy. the results showed an increased lateral-posterior activation as soon as the seizure occurred, suggesting that neuronal loss in the thalamus is not only the consequence of chronic epilepsy. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Neuronal activation
Cell excitability
Pilocarpine
SUDEP
Neuronal loss
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-07-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 28, n. 1, p. 104-107, 2013.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 104-107
Origin http://dx.doi.org/10.1016/j.yebeh.2013.03.025
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000320423500020
URI http://repositorio.unifesp.br/handle/11600/36449

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