Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy

Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy

Author Lopes, Marcio D. Autor UNIFESP Google Scholar
Colugnati, Diego Basile Autor UNIFESP Google Scholar
Lopes, Antonio C. Autor UNIFESP Google Scholar
Scorza, Carla A. Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Cysneiros, Roberta M. Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Goiás (UFG)
Univ Presbiteriana Mackenzie
Abstract Since cardiovascular dysfunction may contribute to sudden unexpected death in epilepsy (SUDEP), the consumption of omega-3 fatty acids (omega-3 FAs) might be beneficial as an adjunctive therapy for SUDEP prevention. It is well recognized that omega-3 FAs exert positive effects on the cardiovascular system including heart rate (HR) reduction, a major risk factor to sudden death. Thus, we evaluated the effects of chronic supplementation of omega-3 FAs on the HR of rats with epilepsy. in agreement with our previous investigations, this study also showed that the HR of animals with epilepsy is higher than that of the control group. Quite interestingly, chronic supplementation with omega-3 FAs restored the HR of rats with epilepsy toward control values. in conclusion, although further investigations are still required, our preliminary results showed a potential preventive effect of omega-3 FA supplementation against SUDEP. (C) 2013 Elsevier Inc. All rights reserved.
Keywords SUDEP
Epilepsy
Heart rate
Pilocarpine
Omega-3 fatty acids (omega-3 FAs)
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-06-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 27, n. 3, p. 504-506, 2013.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 504-506
Origin http://dx.doi.org/10.1016/j.yebeh.2013.02.017
Access rights Closed access
Type Article
Web of Science ID WOS:000318615600014
URI http://repositorio.unifesp.br/handle/11600/36401

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