Incidence of toxoplasma retinochoroiditis in patients after using TNF-alpha blockers

Incidence of toxoplasma retinochoroiditis in patients after using TNF-alpha blockers

Author Paula Rodrigues, Kelly Fernandes de Autor UNIFESP Google Scholar
Faria e Arantes, Tiago Eugenio Autor UNIFESP Google Scholar
Muccioli, Cristina Autor UNIFESP Google Scholar
Andrade Neto, Joao Lins de Autor UNIFESP Google Scholar
Pinheiro, Marcelo M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract TNE-alpha blockers are associated with reactivation of latent granulomatous infections and almost 6% of the world population has some chorioretinitis (CR) caused by Toxoplasma gondii. Thus, the blockade of TNF-alpha could reactivate a latent toxoplasmosis infection (LTxl). This study was conducted to evaluate the prevalence and incidence of chronic and active CR related to T. gondii in patients with ankylosing spondylitis (AS). A total of 74 eyes from 37 active AS outpatients starting TNF alpha blockers were compared with 35 AS patients, matched to age and sex, under conventional therapy in a prospective and controlled trial. All patients underwent serological tests for T. gondii, as well as periodic ophthalmologic examination during 12 months. Active CR was defined if a white, focal retinochoroidal lesion with overlying vitreous inflammation had been found. Retinochoroidal lesions with sharp edges, hyperpigmented borders and atrophic center were defined as CR scars. At baseline, no patient had active CR. From the 144 eyes examined, almost 6% had CR scars and only 2.1% had a typical toxoplasmic CR scar and all of them were negative for HLA-B27. During 12 months of follow-up, no recurrence or new CR were observed. AS patients using TNF-alpha blockers do not have a higher risk of acute or chronic CR caused by T. gondii. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Keywords Toxoplasma
Retinochoroiditis
Ankylosing spondylitis
TNF-alpha blockers
HLA-B27
Prospective study with control group
Language English
Date 2013-06-01
Published in Parasitology International. Clare: Elsevier B.V., v. 62, n. 3, p. 272-275, 2013.
ISSN 1383-5769 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 272-275
Origin http://dx.doi.org/10.1016/j.parint.2013.02.003
Access rights Closed access
Type Article
Web of Science ID WOS:000318752400007
URI http://repositorio.unifesp.br/handle/11600/36398

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