Oligopeptidases B from Trypanossoma cruzi and Trypanossoma brucei Inhibit Inflammatory Pain in Mice by Targeting Serotoninergic Receptors

Oligopeptidases B from Trypanossoma cruzi and Trypanossoma brucei Inhibit Inflammatory Pain in Mice by Targeting Serotoninergic Receptors

Author Abrahao, Rafaela Quintanilha Autor UNIFESP Google Scholar
Franciosi, Adriano Cardoso Google Scholar
Andrade, Douglas Autor UNIFESP Google Scholar
Juliano, Luiz Autor UNIFESP Google Scholar
Juliano, Maria Aparecida Autor UNIFESP Google Scholar
Giorgi, Renata Google Scholar
Dale, Camila Squarzoni Google Scholar
Institution Hosp Sirio Libanes
Universidade Federal de São Paulo (UNIFESP)
Butantan Inst
Abstract In the present study, the antinociceptive profile of oligopeptidases B from Trypanosoma cruzi (OPTc) and Trypanosoma brucei (OPTb) were examined in mice evaluated by the acetic acid-induced writhing test. Both OPTc and OPTb injected intraperitoneally attenuated the writhing numbers in the acetic acid-induced writhing test. This effect was not dependent on the enzymatic activity, but the enzyme structure was important for this purpose. Intraperitoneal pretreatment with methysergide (5-HT serotonergic receptor antagonist) attenuated antinociceptive effect induced by both OPTc and OPTb in the writhing test. However, naloxone (opioid receptor antagonist) or yohimbine (alpha 2-adrenergic receptor antagonist) did not affect antinociception induced by both oligopeptidases. Our results suggest that OPTc and OPTb show antinociceptive property in the writhing test. Furthermore, this antinociceptive effect may be mediated by serotonergic receptor but not opioidergic or alpha 2-adrenergic receptors.
Keywords oligopeptidases B
Trypanossoma cruzi
Trypanossoma brucei
mice
antinociception
hyperalgesia
Language English
Date 2013-06-01
Published in Inflammation. New York: Springer/plenum Publishers, v. 36, n. 3, p. 705-712, 2013.
ISSN 0360-3997 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 705-712
Origin http://dx.doi.org/10.1007/s10753-013-9595-1
Access rights Closed access
Type Article
Web of Science ID WOS:000320706000022
URI http://repositorio.unifesp.br/handle/11600/36382

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account