Safety and diagnostic accuracy of neuroendoscopic biopsies: an international multicenter study

Safety and diagnostic accuracy of neuroendoscopic biopsies: an international multicenter study

Author Constantini, Shlomi Google Scholar
Mohanty, Aaron Google Scholar
Zymberg, Samuel Tau Autor UNIFESP Google Scholar
Cavalheiro, Sergio Autor UNIFESP Google Scholar
Mallucci, Conor Google Scholar
Hellwig, Dieter Google Scholar
Ersahin, Yusuf Google Scholar
Mori, Hiroshi Google Scholar
Mascari, Carmelo Google Scholar
Costa Val, Jose Aloysio Google Scholar
Wagner, Wolfgang Google Scholar
Kulkarni, Abhaya V. Google Scholar
Sgouros, Spyros Google Scholar
Oi, Shizuo Google Scholar
Institution Tel Aviv Univ
Univ Texas Med Branch
Universidade Federal de São Paulo (UNIFESP)
Alder Hey Childrens NHS Fdn Trust
Int Neurosci Inst
Ege Univ
Sannocho Hosp
Univ Bologna
Biocor Inst
Univ Hosp
Hosp Sick Children
Univ Athens
Mitera Childrens Hosp
Jikei Univ
Abstract Object. Analysis of the safety and morbidity of neuroendoscopic biopsies (NEBs), as well as the reliability in obtaining an accurate diagnosis, has until now been based on studies with relatively small sample sizes. Through the cooperative efforts of several international medical centers, authors of the present study collected data on a large number of patients to obtain better insight into this issue. When possible, they compared pathology obtained through an NEB with the gold-standard pathology obtained in open surgery.Methods. Thirteen randomly chosen medical centers in 9 countries collected data for patients who had undergone NEB, which were then analyzed for universal complications, bleeding, navigation technique, pathology, mismatch between biopsy results and final diagnosis, and a number of other potentially influential factors.Results. Data for 293 patients were analyzed. Sixty percent of the patients were male, and patient ages ranged from 0.1 to 78.7 years (median age 20.4 years). the most common tumor locations were pineal (33.1%), thalamic (16.7%), tectal (13%), and hypothalamic (4.4%). Fifty percent of the tumors were larger than 20 mm, 36% were between 10 and 20 mm, and 14% were smaller than 10 mm. Intraoperative bleeding was seen in 275 patients (94%). the amount of blood was noted as mild in 75%, moderate in 13%, and severe in 6%. Infection occurred in 8 patients (3%). Death occurred in 1 patient (0.3%), which was caused by severe intraoperative bleeding. Biopsies were informative in 265 patients (90.4%). Seventy-eight patients (26.6%) had open surgery following the NEB. for these patients, the pathology results from the NEB were compared with those from the open surgery that followed. in 14 cases (17.9%) there was disagreement on the pathology. of these cases, a meaningful mismatch, in which the erroneous NEB pathology could have led to an inappropriate management decision, occurred in 9 cases (11.5%). Most of these meaningful mismatches were lesions diagnosed as low-grade or pilocytic astrocytoma on the NEB and later proved to be high-grade astrocytoma (4 cases) and 1 case each of meningioma, cavernoma, primitive neuroectodermal tumor, neurocysticercosis, and pineocytoma.Conclusions. in experienced hands, NEBs can be performed with low morbidity and mortality, providing meaningful pathological data for the majority of patients with a wide range of tumor types, locations, and presentations. These biopsies also offer other advantages, such as the ability to perform concomitant endoscopic third ventriculostomy and septum pellucidotomy. However, due caution must be maintained, since pathology obtained from an NEB, as with stereotactic biopsies, may be subject to sampling errors, especially when the results seem to indicate a low-grade glial tumor.
Keywords endoscopy
neuropathology
brain tumor
stereotactic biopsy
neuroendoscopic biopsy
Language English
Sponsor International Federation of Neuroendoscopy
Date 2013-06-01
Published in Journal of Neurosurgery-pediatrics. Rolling Meadows: Amer Assoc Neurological Surgeons, v. 11, n. 6, p. 704-709, 2013.
ISSN 1933-0707 (Sherpa/Romeo, impact factor)
Publisher Amer Assoc Neurological Surgeons
Extent 704-709
Origin http://dx.doi.org/10.3171/2013.3.PEDS12416
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000319366900015
URI http://repositorio.unifesp.br/handle/11600/36373

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