Yerba mate extract (Ilex paraguariensis) attenuates both central and peripheral inflammatory effects of diet-induced obesity in rats

Yerba mate extract (Ilex paraguariensis) attenuates both central and peripheral inflammatory effects of diet-induced obesity in rats

Author Pimentel, Gustavo D. Autor UNIFESP Google Scholar
Lira, Fabio S. Autor UNIFESP Google Scholar
Rosa, Jose C. Autor UNIFESP Google Scholar
Caris, Aline V. Autor UNIFESP Google Scholar
Pinheiro, Fernanda Autor UNIFESP Google Scholar
Ribeiro, Eliane B. Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia M. Autor UNIFESP Google Scholar
Oyama, Lila M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract To clarify the effects of natural dietary components on the metabolic consequences of obesity, we examined the effects of yerba mate extract Ilex paraguariensis on both central and peripheral inflammatory effects of diet-induced obesity and correlated the hypothalamic tumor necrosis factor (TNF)-alpha level with adipose depot weight. Wistar rats were divided into four groups: a control group (CTL) fed with chow diet, a second group fed with chow diet plus yerba mate extract (CTL+E), a third group fed with a high-fat diet rich in saturated fatty acids (HFD) and a fourth group fed with HFD plus yerba mate extract (HFD+E). Enzyme-linked immunosorbent assay, Western blotting, colorimetric method and treatment by gavage were utilized as materials and methods. the HFD groups showed a significant increase in food intake (kcal), body weight, adipose tissue and leptin level in comparison to CTL and CTL+E. HFD leads to increase of both central and peripheral inflammatory effects, and deregulation of insulin pathway. in addition, yerba mate extract intake blunted the proinflammatory effects of diet-induced obesity in rats by reducing the phosphorylation of hypothalamic IKK and NFKBp65 expression and increasing the protein levels of IKBoe, the expression of adiponectin receptor-1 and consequently the amount of IRS-2. Moreover, the increase in interleukin (IL)-6 levels in the liver and muscle and of the IL-10/TNF-alpha ratio in groups that received yerba mate extract showed the anti-inflammatory effects of this natural substance. Taken together, our data suggest that the use of yerba mate extract may be useful for reducing low-grade obesity-associated inflammation. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Yerba mate extract
Diet-induced obesity
High-fat diet
Inflammation
Cytokines
Insulin resistance
Rat
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2009/14373-8
FAPESP: 2009/11398-0
Date 2013-05-01
Published in Journal of Nutritional Biochemistry. New York: Elsevier B.V., v. 24, n. 5, p. 809-818, 2013.
ISSN 0955-2863 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 809-818
Origin http://dx.doi.org/10.1016/j.jnutbio.2012.04.016
Access rights Closed access
Type Article
Web of Science ID WOS:000318825600011
URI http://repositorio.unifesp.br/handle/11600/36293

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