The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage

The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage

Author Picão, Renata Cristina Autor UNIFESP Google Scholar
Cardoso, Juliana Pereira Autor UNIFESP Google Scholar
Campana, Eloiza Helena Autor UNIFESP Google Scholar
Nicoletti, Adriana Giannini Autor UNIFESP Google Scholar
Petrolini, Fernanda Villas Boas Autor UNIFESP Google Scholar
Assis, Diego Magno Autor UNIFESP Google Scholar
Juliano, Luiz Autor UNIFESP Google Scholar
Gales, Ana Cristina Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Fundacao Parque Zool São Paulo
Abstract We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. the presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Carbapenemases
bla(KPC) dissemination
Wastewater
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Sanofi-Aventis
Thermo Fisher
bioMerieux
Grant number FAPESP: 2009/11051-0
CNPq: 307816/2009-5
CNPq: 302981/2011-0
Date 2013-05-01
Published in Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 76, n. 1, p. 80-85, 2013.
ISSN 0732-8893 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 80-85
Origin http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000318325900016
URI http://repositorio.unifesp.br/handle/11600/36224

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