Cognitive impairment in Brazilian patients with Behcet's disease occurs independently of neurologic manifestation

Cognitive impairment in Brazilian patients with Behcet's disease occurs independently of neurologic manifestation

Author Dutra, Livia Almeida Autor UNIFESP Google Scholar
Silva de Souza, Alexandre Wagner Autor UNIFESP Google Scholar
Alessi, Helena Autor UNIFESP Google Scholar
Sobreira Guedes, Bruno de Vasconcelos Google Scholar
Braga-Neto, Pedro Autor UNIFESP Google Scholar
Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Goncalves, Celio Roberto Google Scholar
Rocha, Antonio Jose da Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Barsottini, Orlando Graziani Povoas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Ciencias Med Santa Casa São Paulo
Universidade de São Paulo (USP)
Abstract Neuro-Behcet's disease (NBD) presents cognitive and behavioral symptoms possibly explained by secondary dysfunction of frontal and temporal cortices due to subcortical damage, as NBD commonly involves the brainstem and basal ganglia. Nonetheless, there are reports of cognitive impairment in patients without neurological manifestations.Objective: To evaluate cognitive function in Behcet's disease (BD) patients with and without neurological manifestations and to analyze clinical variables associated with cognitive deficits.Methods: This is a cross-sectional study that compared healthy controls, BD patients without neurological manifestations and NBD patients. Each group comprised 24 participants. All participants underwent neuropsychological evaluation, Hamilton Anxiety Rating Scale (HAM-A), Beck Depression Inventory (BDI) application and brain MRI. Cumulative prednisone dose, years of education, and presence of white-matter lesions in brain MRI were recorded.Results: 41.6% of BD and 41.6% of NBD patients showed impaired language and executive function, whereas visual memory was impaired only in NBD patients. Multiple logistic regression revealed that anxiety (OR 1.09 95% CI 1.03-1.16, p = 0.003) and lower educational level (OR 0.62 95% CI 0.48-0.80, p<0.0001) were independently associated with cognitive impairment.Conclusion: Cognitive impairment occurs frequently in patients with BD independently of neurological manifestation. Low educational level and anxiety are risk factors for cognitive impairment in BD. (c) 2013 Elsevier B.V. All rights reserved.
Keywords Behcet's syndrome
Neuro-Behcet's disease
Cognitive dysfunction
Neuropsychology
Memory
Anxiety
Educational level
Language English
Date 2013-04-15
Published in Journal of the Neurological Sciences. Amsterdam: Elsevier B.V., v. 327, n. 1-2, p. 1-5, 2013.
ISSN 0022-510X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1-5
Origin http://dx.doi.org/10.1016/j.jns.2013.01.024
Access rights Closed access
Type Article
Web of Science ID WOS:000317552600001
URI http://repositorio.unifesp.br/handle/11600/36212

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