Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin

Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin

Author Souza, Lucas R. de Google Scholar
Melo, Pollyana Maria Saud Autor UNIFESP Google Scholar
Paschoalin, Thaysa Autor UNIFESP Google Scholar
Carmona, Adriana Karaoglanovic Autor UNIFESP Google Scholar
Kondo, Marcia Yuri Autor UNIFESP Google Scholar
Hirata, Izaura Yoshico Autor UNIFESP Google Scholar
Blaber, Michael Google Scholar
Tersariol, Ivarne Luis dos Santos Autor UNIFESP Google Scholar
Takatsuka, Joyce Google Scholar
Juliano, Maria Aparecida Autor UNIFESP Google Scholar
Juliano, Luiz Autor UNIFESP Google Scholar
Gomes, Roseli A. Google Scholar
Puzer, Luciano Google Scholar
Institution Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Florida State Univ
Univ Mogi das Cruzes
Univ Fed Triangulo Mineiro
Abstract Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Plasminogen
Plasmin
Kallikrein
Protease
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Grant number FAPESP: Proc 2011/51297-8
CNPq: 312701/2009-8
Date 2013-04-12
Published in Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013.
ISSN 0006-291X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 333-337
Origin http://dx.doi.org/10.1016/j.bbrc.2013.03.001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000318190400012
URI http://repositorio.unifesp.br/handle/11600/36204

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