ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia

ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia

Author Ota, Vanessa K. Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Assuncao, Idaiane B. Autor UNIFESP Google Scholar
Santoro, Marcos L. Autor UNIFESP Google Scholar
Christofolini, Denise M. Google Scholar
Bellucco, Fernanda T. Autor UNIFESP Google Scholar
Santos-Filho, Airton F. Autor UNIFESP Google Scholar
Ottoni, Gustavo L. Google Scholar
Lara, Diogo R. Google Scholar
Mari, Jair J. Autor UNIFESP Google Scholar
Melaragno, Maria I. Autor UNIFESP Google Scholar
Smith, Marilia A. C. Autor UNIFESP Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Belangero, Sintia I. Autor UNIFESP Google Scholar
Jackowski, Andrea P. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
FMABC
Pontificia Univ Rio Grande Sul PUCRS
Abstract ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes. (C) 2013 Elsevier B. V. All rights reserved.
Keywords Schizophrenia
ZDHHC8
22q11
Cortical volumes
MRI
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: FAPESP 2007/58736-1
FAPESP: 2011/00030-1
Date 2013-04-01
Published in Schizophrenia Research. Amsterdam: Elsevier B.V., v. 145, n. 1-3, p. 33-35, 2013.
ISSN 0920-9964 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 33-35
Origin http://dx.doi.org/10.1016/j.schres.2013.01.011
Access rights Closed access
Type Article
Web of Science ID WOS:000317336200005
URI http://repositorio.unifesp.br/handle/11600/36168

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