Basiliximab induction in patients receiving tacrolimus-based immunosuppressive regimens

Basiliximab induction in patients receiving tacrolimus-based immunosuppressive regimens

Author Sandes-Freitas, Taina Veras de Autor UNIFESP Google Scholar
Felipe, Claudia Rosso Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Tedesco-Silva, Helio Autor UNIFESP Google Scholar
Medina-Pestana, Jose Osmar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The use of basiliximab induction increased significantly in recent years based on its superior efficacy and excellent safety profile demonstrated in studies with cyclosporine-based immunosuppression. However, its clinical utility in patients receiving tacrolimus-based immunosuppressive regimens is still uncertain.We retrospectively reviewed data of 366 low immunological risk recipients of deceased donor kidney transplants. of them, 134 received basiliximab and tacrolimus (TAC-IL2-RA), 100 received basiliximab and delayed tacrolimus(dTAC-IL2-RA), and 132 patients received tacrolimus without basiliximab(TAC-No). the endpoints were the incidence of acute rejection, graft function, and patient and graft survivals at 1 year.The incidence of acute rejection was higher in dTAC-IL2-RA compared to TAC-IL-2RA and TAC-No Groups (33 vs.14.9 vs. 14.3 %, p < 0.001). Inferior creatinine clearance was observed in dTAC-IL2-RA Group compared to TAC-IL2-RA and TAC-No Groups at months 1 (41.6 vs. 49.9 vs. 44.8 mL/min, p = 0.004), 3 (49.8 vs. 57.2 vs. 53.5 mL/min, p = 0.017), and 6 (53.1 vs. 61.8 vs. 57.0 mL/min, p = 0.001). Patients who received basiliximab (TAC-IL2-RA and dTAC-IL2-RA Groups) had lower incidence of posttransplant diabetes (24 vs.18 vs. 39.3 %, p = 0.009). Patient and graft survivals were similar among the groups.In low immunological risk kidney transplant recipients receiving tacrolimus, the use of basiliximab induction was not associated with lower rejection rates and did not allow delayed tacrolimus introduction.
Keywords Basiliximab
Tacrolimus
Kidney transplantation
Induction therapy
Language English
Date 2013-04-01
Published in International Urology and Nephrology. Dordrecht: Springer, v. 45, n. 2, p. 537-546, 2013.
ISSN 0301-1623 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 537-546
Origin http://dx.doi.org/10.1007/s11255-012-0298-6
Access rights Closed access
Type Article
Web of Science ID WOS:000316333600032
URI http://repositorio.unifesp.br/handle/11600/36149

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