Sexual response in female rats with status epilepticus

Show simple item record

dc.contributor.author Alvarenga, Tathiana A. [UNIFESP]
dc.contributor.author Matos, Gabriela [UNIFESP]
dc.contributor.author Scorza, Fulvio A. [UNIFESP]
dc.contributor.author Amado, Debora [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrão [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:28Z
dc.date.available 2016-01-24T14:31:28Z
dc.date.issued 2013-04-01
dc.identifier http://dx.doi.org/10.1111/epi.12117
dc.identifier.citation Epilepsia. Hoboken: Wiley-Blackwell, v. 54, n. 4, p. 644-648, 2013.
dc.identifier.issn 0013-9580
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36119
dc.description.abstract Purpose Female sexual function is complex and may be disrupted by disease, in particular epilepsy. Chronic seizures in women can have adverse effects on reproductive function, but it has been difficult to dissociate the effects of epilepsy from those related to anticonvulsant medications. the purpose of this study was to evaluate sexual behavior in female rats submitted to pilocarpine-induced status epilepticus (SE). Methods Adult female Wistar rats were given saline or pilocarpine (350mg/kg, i.p.) to induce SE. the groups were distributed according to the treatment or response to pilocarpine: CTRL (control rats maintained in the home-cage after saline administration); NSE (nonstatus epilepticus, rats that did not display convulsive and intermittent seizures after pilocarpine injection) and SE (status epilepticus, rats that displayed convulsive and intermittent seizures after pilocarpine injection). After 50days, sexual receptivity in the female rats was artificially induced via administration of a combination of estradiol and progesterone. Sexual behavior was evaluated during three sessions in the presence of a sexually experienced male rat. Receptivity and proceptivity behaviors, as well as hormones concentrations, were monitored. Key Findings Significant decreases in proceptivity and receptivity behaviors during the three tests were observed in SE female rats. the rejection response was significantly increased in SE rats compared with CTRL or NSE groups. Progesterone, testosterone, and corticosterone were unchanged between the groups. Significance the SE female rats showed lower sexual motivation and performance regardless of their steroid hormones levels. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 644-648
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Epilepsia
dc.rights Acesso aberto
dc.subject Sexual behavior en
dc.subject Pilocarpine model en
dc.subject Epilepsy en
dc.subject Hormones en
dc.subject Female rats en
dc.title Sexual response in female rats with status epilepticus en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Neurol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Neurol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 10/15110-8
dc.description.sponsorshipID FAPESP: 11/12325-6
dc.description.sponsorshipID FAPESP: 12/05396-7
dc.identifier.doi 10.1111/epi.12117
dc.description.source Web of Science
dc.identifier.wos WOS:000316965500013



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account