Sexual response in female rats with status epilepticus

Sexual response in female rats with status epilepticus

Author Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Matos, Gabriela Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose Female sexual function is complex and may be disrupted by disease, in particular epilepsy. Chronic seizures in women can have adverse effects on reproductive function, but it has been difficult to dissociate the effects of epilepsy from those related to anticonvulsant medications. the purpose of this study was to evaluate sexual behavior in female rats submitted to pilocarpine-induced status epilepticus (SE). Methods Adult female Wistar rats were given saline or pilocarpine (350mg/kg, i.p.) to induce SE. the groups were distributed according to the treatment or response to pilocarpine: CTRL (control rats maintained in the home-cage after saline administration); NSE (nonstatus epilepticus, rats that did not display convulsive and intermittent seizures after pilocarpine injection) and SE (status epilepticus, rats that displayed convulsive and intermittent seizures after pilocarpine injection). After 50days, sexual receptivity in the female rats was artificially induced via administration of a combination of estradiol and progesterone. Sexual behavior was evaluated during three sessions in the presence of a sexually experienced male rat. Receptivity and proceptivity behaviors, as well as hormones concentrations, were monitored. Key Findings Significant decreases in proceptivity and receptivity behaviors during the three tests were observed in SE female rats. the rejection response was significantly increased in SE rats compared with CTRL or NSE groups. Progesterone, testosterone, and corticosterone were unchanged between the groups. Significance the SE female rats showed lower sexual motivation and performance regardless of their steroid hormones levels.
Keywords Sexual behavior
Pilocarpine model
Epilepsy
Hormones
Female rats
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 10/15110-8
FAPESP: 11/12325-6
FAPESP: 12/05396-7
Date 2013-04-01
Published in Epilepsia. Hoboken: Wiley-Blackwell, v. 54, n. 4, p. 644-648, 2013.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 644-648
Origin http://dx.doi.org/10.1111/epi.12117
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316965500013
URI http://repositorio.unifesp.br/handle/11600/36119

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