Consequences of Obstructive Sleep Apnea on Metabolic Profile: A Population-Based Survey

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dc.contributor.author Togeiro, Sonia Maria [UNIFESP]
dc.contributor.author Carneiro, Glaucia [UNIFESP]
dc.contributor.author Ribeiro Filho, Fernando Flexa [UNIFESP]
dc.contributor.author Zanella, Maria Teresa [UNIFESP]
dc.contributor.author Santos-Silva, Rogerio [UNIFESP]
dc.contributor.author Taddei, Jose A. [UNIFESP]
dc.contributor.author Bittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:27Z
dc.date.available 2016-01-24T14:31:27Z
dc.date.issued 2013-04-01
dc.identifier http://dx.doi.org/10.1002/oby.20288
dc.identifier.citation Obesity. Hoboken: Wiley-Blackwell, v. 21, n. 4, p. 847-851, 2013.
dc.identifier.issn 1930-7381
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36113
dc.description.abstract Objective: Epidemiologic studies that control for potential confounders are needed to assess the independent associations of obstructive sleep apnea (OSA) with metabolic abnormalities. the aim of our study was to evaluate the associations of OSA with metabolic abnormalities among the adult population of São Paulo, Brazil.Design and Methods: Questionnaires were applied face-to-face, full night polysomnography (PSG) was performed, and blood samples were collected in a population-based survey in São Paulo, Brazil, adopting a probabilistic three-stage cluster sample method. the metabolic profile included fasting glucose, insulin, and lipid levels. the hepatic insulin resistance index was assessed by the homeostasis model assessment-estimated insulin resistance (HOMA(IR)).Results: A total of 1,042 volunteers underwent PSG. Mild OSA and moderate to severe OSA comprised 21.2% and 16.7% of the population, respectively. Subjects with severe to moderate OSA were older, more obese, had higher fasting glucose, HOMA(IR), and triglycerides (TG) levels than did the mild and non-OSA group (P < 0.001). Multivariate regression analyses showed that an apnea-hypopnea index (AHI) >= 15 and a time of oxy-hemoglobin saturation <90% were independently associated with impaired fasting glucose, elevated TG, and HOMA(IR).Conclusions: the results of this large cross-sectional epidemiological study showed that the associations of OSA and metabolic abnormalities were independent of other risk factors. en
dc.description.sponsorship Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 847-851
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Obesity
dc.rights Acesso aberto
dc.title Consequences of Obstructive Sleep Apnea on Metabolic Profile: A Population-Based Survey en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Disciplina Endocrinol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, Disciplina Nutr & Metab, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Disciplina Endocrinol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, Disciplina Nutr & Metab, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 07/50525-1
dc.description.sponsorshipID FAPESP: 98/14303-3
dc.identifier.doi 10.1002/oby.20288
dc.description.source Web of Science
dc.identifier.wos WOS:000322087800027



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