Consequences of Obstructive Sleep Apnea on Metabolic Profile: A Population-Based Survey

Consequences of Obstructive Sleep Apnea on Metabolic Profile: A Population-Based Survey

Author Togeiro, Sonia Maria Autor UNIFESP Google Scholar
Carneiro, Glaucia Autor UNIFESP Google Scholar
Ribeiro Filho, Fernando Flexa Autor UNIFESP Google Scholar
Zanella, Maria Teresa Autor UNIFESP Google Scholar
Santos-Silva, Rogerio Autor UNIFESP Google Scholar
Taddei, Jose A. Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: Epidemiologic studies that control for potential confounders are needed to assess the independent associations of obstructive sleep apnea (OSA) with metabolic abnormalities. the aim of our study was to evaluate the associations of OSA with metabolic abnormalities among the adult population of São Paulo, Brazil.Design and Methods: Questionnaires were applied face-to-face, full night polysomnography (PSG) was performed, and blood samples were collected in a population-based survey in São Paulo, Brazil, adopting a probabilistic three-stage cluster sample method. the metabolic profile included fasting glucose, insulin, and lipid levels. the hepatic insulin resistance index was assessed by the homeostasis model assessment-estimated insulin resistance (HOMA(IR)).Results: A total of 1,042 volunteers underwent PSG. Mild OSA and moderate to severe OSA comprised 21.2% and 16.7% of the population, respectively. Subjects with severe to moderate OSA were older, more obese, had higher fasting glucose, HOMA(IR), and triglycerides (TG) levels than did the mild and non-OSA group (P < 0.001). Multivariate regression analyses showed that an apnea-hypopnea index (AHI) >= 15 and a time of oxy-hemoglobin saturation <90% were independently associated with impaired fasting glucose, elevated TG, and HOMA(IR).Conclusions: the results of this large cross-sectional epidemiological study showed that the associations of OSA and metabolic abnormalities were independent of other risk factors.
Language English
Sponsor Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/50525-1
FAPESP: 98/14303-3
Date 2013-04-01
Published in Obesity. Hoboken: Wiley-Blackwell, v. 21, n. 4, p. 847-851, 2013.
ISSN 1930-7381 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 847-851
Origin http://dx.doi.org/10.1002/oby.20288
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000322087800027
URI http://repositorio.unifesp.br/handle/11600/36113

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