Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

Author Almeida, Valéria de Autor UNIFESP Google Scholar
Levin, Raquel Autor UNIFESP Google Scholar
Peres, Fernanda Fiel Autor UNIFESP Google Scholar
Niigaki, Suzy Tamie Autor UNIFESP Google Scholar
Calzavara, Mariana Bendlin Autor UNIFESP Google Scholar
Zuardi, Antonio Waldo Google Scholar
Hallak, Jaime Eduardo Cecilio Google Scholar
Crippa, José Alexandre de Souza Google Scholar
Abílio, Vanessa Costhek Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Inst Nacl Ciencia & Tecnol Translac Med
Abstract Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. in addition, SHRs present a hyperlocomotion that is reverted by typical and atypical antipsychotics, suggesting that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and positive symptoms (modeled by hyperlocomotion) of schizophrenia as well as the effects of potential antipsychotics drugs. At the same time, an increase in social interaction in control animals similar to that induced by benzodiazepines is used to screen potential anxiolytic drugs. the aim of this study was to investigate the effects of CBD on social interaction presented by control animals (Wistar) and SHRs. the lowest dose of CBD (1 mg/kg) increased passive and total social interaction of Wistar rats. However, the hyperlocomotion and the deficit in social interaction displayed by SHRs were not altered by any dose of CBD. Our results do not support an antipsychotic property of cannabidiol on symptoms-like behaviors in SHRs but reinforce the anxiolytic profile of this compound in control rats. (C) 2012 Elsevier Inc. All rights reserved.
Keywords Anxiety
Cannabidiol
Schizophrenia
SHR
Social interaction test
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: FAPESP - 2010/07994-3
Date 2013-03-05
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 41, p. 30-35, 2013.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 30-35
Origin http://dx.doi.org/10.1016/j.pnpbp.2012.10.024
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000315324600006
URI http://repositorio.unifesp.br/handle/11600/36076

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