Homocysteine Levels in Takayasu Arteritis - A Risk Factor for Arterial Ischemic Events

Homocysteine Levels in Takayasu Arteritis - A Risk Factor for Arterial Ischemic Events

Author Silva de Souza, Alexandre Wagner Autor UNIFESP Google Scholar
De Lima, Carla Serrano Autor UNIFESP Google Scholar
Oliveira, Cecilia Diniz Autor UNIFESP Google Scholar
Gomes Machado, Luiz Samuel Autor UNIFESP Google Scholar
Gurgel Pinheiro, Frederico Augusto Autor UNIFESP Google Scholar
Hix, Sonia Autor UNIFESP Google Scholar
D' Almeida, Vania Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective. To evaluate homocysteine levels in patients with Takayasu arteritis (TA) and in controls, and to analyze associations between homocysteine levels and paraoxonase 1 (PON1) activity, cysteine levels, methotrexate use, disease activity, extent of arterial involvement, and ischemic events in patients with TA.Methods. A cross-sectional study was performed with 29 patients with TA and 30 controls who underwent clinical evaluation and blood sample collection in the fasting state.Results. Among patients with TA, active disease was observed in 9 (31.0%) and previous arterial ischemic events in 10 (34.5%). Therapy with methotrexate was prescribed to 9 (31.0%) patients and it was associated with folic acid in 8 cases. Median homocysteine level was higher in patients with TA [10.9 mu mol/l, interquartile range (IQR) 9.6-14.8] than in controls (6.9 mu mol/l, IQR 5.1-11.9; p<0.001). No difference was found regarding mean homocysteine levels between those using methotrexate and those under other therapies (12.8 +/- 5.3 mu mol/l vs 12.1 +/- 3.2 mu mol/l, respectively;, p = 0.662). TA patients with active disease presented lower homocysteine levels (10.4 +/- 2.1 mu mol/l) compared to TA patients in remission (13.1 +/- 4.2 mu mol/l) (p = 0.034). A significant correlation was found between cysteine and homocysteine levels in patients with TA (p = 0.676, p<0.0001), while there was no correlation between homocysteine and PON1 activity (p = 0.214, p = 0.265). Median homocysteine levels were higher in patients with ischemic events (13.2 mu mol/l, IQR 10.9-17.5) compared to patients with no ischemic events (9.8 mu mol/l, IQR 8.7-14.7; p = 0.027) and were associated with arterial ischemia in patients with TA (OR 1.31, 95% CI 1.01-1.71, p = 0.041).Conclusion. Patients with TA presented higher homocysteine levels than controls and homocysteine was associated with an increased risk of arterial ischemic events in TA. (First Release Dec 15 2012; I Rheumatol 2013;40:303-8; doi:10.3899/jrheum.121073)
Keywords TAKAYASU ARTERITIS
HOMOCYSTEINE
THROMBOSIS
ARTERIAL INFLAMMATION
Language English
Date 2013-03-01
Published in Journal of Rheumatology. Toronto: J Rheumatol Publ Co, v. 40, n. 3, p. 303-308, 2013.
ISSN 0315-162X (Sherpa/Romeo, impact factor)
Publisher J Rheumatol Publ Co
Extent 303-308
Origin http://dx.doi.org/10.3899/jrheum.121073
Access rights Closed access
Type Article
Web of Science ID WOS:000316527500015
URI http://repositorio.unifesp.br/handle/11600/36074

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