Animal models of skin disease for drug discovery

Animal models of skin disease for drug discovery

Author Avci, Pinar Google Scholar
Sadasivam, Magesh Google Scholar
Gupta, Asheesh Google Scholar
De Melo, Wanessa C. M. A. Autor UNIFESP Google Scholar
Huang, Ying-Ying Google Scholar
Yin, Rui Google Scholar
Chandran, Rakkiyappan Google Scholar
Kumar, Raj Google Scholar
Otufowora, Ayodeji Google Scholar
Nyame, Theodore Google Scholar
Hamblin, Michael R. Google Scholar
Institution Massachusetts Gen Hosp
Harvard Univ
Def Inst Physiol & Allied
Universidade Federal de São Paulo (UNIFESP)
Third Mil Med Univ
Amity Univ Uttar Pradesh
Guangxi Med Univ
Harvard Div Hlth Sci & Technol
Abstract Introduction: Discovery of novel drugs, treatments, and testing of consumer products in the field of dermatology is a multi-billion dollar business. Due to the distressing nature of many dermatological diseases, and the enormous consumer demand for products to reverse the effects of skin photodamage, aging, and hair loss, this is a very active field.Areas covered: in this paper, we will cover the use of animal models that have been reported to recapitulate to a greater or lesser extent the features of human dermatological disease. There has been a remarkable increase in the number and variety of transgenic mouse models in recent years, and the basic strategy for constructing them is outlined.Expert opinion: Inflammatory and autoimmune skin diseases are all represented by a range of mouse models both transgenic and normal. Skin cancer is mainly studied in mice and fish. Wound healing is studied in a wider range of animal species, and skin infections such as acne and leprosy also have been studied in animal models. Moving to the more consumer-oriented area of dermatology, there are models for studying the harmful effect of sunlight on the skin, and testing of sunscreens, and several different animal models of hair loss or alopecia.
Keywords alopecia
animal models
dermatitis
dermatology
dermatomyositis
psoriasis
scleroderma
skin cancer
transgenic mouse models
wound healing
Language English
Sponsor US NIH
Department of Science and Technology, Government of India (BOYCAST Fellowship)
National Natural Science Foundation of China
Grant number US NIH: R01AI050875
National Natural Science Foundation of China: 81172495
Date 2013-03-01
Published in Expert Opinion On Drug Discovery. London: Informa Healthcare, v. 8, n. 3, p. 331-355, 2013.
ISSN 1746-0441 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 331-355
Origin http://dx.doi.org/10.1517/17460441.2013.761202
Access rights Closed access
Type Review
Web of Science ID WOS:000315166000007
URI http://repositorio.unifesp.br/handle/11600/36070

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