Fluoroquinolone susceptibilities to methicillin-resistant and susceptible coagulase-negative Staphylococcus isolated from eye infection

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dc.contributor.author Oliveira, Adália Dias Dourado [UNIFESP]
dc.contributor.author Hofling-Lima, Ana Luisa [UNIFESP]
dc.contributor.author Belfort, Rubens Junior [UNIFESP]
dc.contributor.author Gayoso, Maria de Fátima
dc.contributor.author Francisco, Waldemar
dc.date.accessioned 2015-06-14T13:36:48Z
dc.date.available 2015-06-14T13:36:48Z
dc.date.issued 2007-03-01
dc.identifier http://dx.doi.org/10.1590/S0004-27492007000200018
dc.identifier.citation Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 70, n. 2, p. 286-289, 2007.
dc.identifier.issn 0004-2749
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/3605
dc.description.abstract PURPOSE: To evaluate the fluoroquinolone susceptibilities of ocular isolate coagulase-negative staphylococci (CoNS), identified at the Microbiology Laboratory - UNIFESP. DESIGN: Experimental laboratory investigation. METHODS: The minimum inhibitory concentrations (MICs) of 21 strains of methicillin-resistant coagulase-negative staphylococci (MRCoNS) and 22 methicillin-sensitive coagulase-negative staphylococci (MSCoNS) to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin were determined, using the E-test method standardized by the Clinical and Laboratory Standards Institute (CLSI/NCCLS). RESULTS: The MIC90s (µg/ml) for the second generation of tested fluoroquinolones were higher than the fourth generation, especially for the methicillin-resistant coagulase-negative staphylococci group. CONCLUSION: Our results indicate that methicillin-sensitive coagulase-negative staphylococci are more susceptible to quinolones than are methicillin-resistant coagulase-negative staphylococci and that fourth generation fluoroquinolones appear to be more potent, affecting even coagulase-negative staphylococcal strains resistant to second generation fluoroquinolones. en
dc.description.abstract OBJETIVOS: Avaliar a suscetibilidade a fluorquinolonas dos Staphylococcus coagulase-negativo (SCoN) identificados no Laboratório de Microbiologia Ocular da UNIFESP. MÉTODOS: Foi determinada a concentração inibitória mínima de 21 cepas de SCoN meticilina-resistentes e 22 meticilina-sensíveis para ciprofloxacina, ofloxacina, gatifloxacina e moxifloxacina, utilizando o E-test estandartizado pelo CLSI/NCCLS. RESULTADOS: Os MIC90 (µg/ml) de 43 SCoN isolados para fluorquinolonas de segunda geração foram maiores do que os de quarta geração, principalmente para o grupo dos meticilina-resistentes. CONCLUSÃO: Nossos resultados indicam que Staphylococcus coagulase-negativo meticilina-sensíveis são mais suscetíveis às quinolonas do que os Staphylococcus coagulase-negativo meticilina-resistentes, fluorquinolonas de quarta geração parecem ser mais potentes, cobrindo inclusive cepas de Staphylococcus coagulase-negativo resistentes à segunda geração de fluorquinolonas. pt
dc.format.extent 286-289
dc.language.iso eng
dc.publisher Conselho Brasileiro de Oftalmologia
dc.relation.ispartof Arquivos Brasileiros de Oftalmologia
dc.rights Acesso aberto
dc.subject Drug resistance en
dc.subject Eye infections, bacterial en
dc.subject Staphylococcus en
dc.subject Coagulase en
dc.subject Fluoroquinolones en
dc.subject Methicillin-resistance en
dc.subject Resistência microbiana a drogas pt
dc.subject Infecções oculares bacterianas pt
dc.subject Staphylococcus pt
dc.subject Coagulase pt
dc.subject Fluoroquinolonas pt
dc.subject Resistência a meticilina pt
dc.title Fluoroquinolone susceptibilities to methicillin-resistant and susceptible coagulase-negative Staphylococcus isolated from eye infection en
dc.title.alternative Suscetibilidade dos Staphylococcus coagulase negativo meticilina-resistentes e suscetíveis isolados em infecções oculares pt
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIFESP Departamento de Oftalmologia
dc.description.affiliation Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas
dc.description.affiliationUnifesp UNIFESP, Depto. de Oftalmologia
dc.identifier.file S0004-27492007000200018.pdf
dc.identifier.scielo S0004-27492007000200018
dc.identifier.doi 10.1590/S0004-27492007000200018
dc.description.source SciELO



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