Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats

Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats

Author Tenório, Neuli Maria Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Cintra, Fátima Dumas Autor UNIFESP Google Scholar
Alvarenga, Tathiana Aparecida Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: There is a reciprocal relationship between sleep duration and weight gain. However, the consequences of this relationship on the cardiovascular system over an entire life span are still not fully elucidated. We examined the effect of acute sleep deprivation (SD) on baroreflex sensitivity and blood pressure in Zucker rats of different ages.Design and Methods: Female lean and obese Zucker rats at 3, 6 and 15 months of age were assigned to SD or control (CTRL) groups. After a 6 h period of the SD procedure (6 h of gentle handling) or CTRL procedure (an equivalent period without handling), the animals were anesthetized for surgical catheterization of the femoral artery and vein. To evaluate the baroreflex sensitivity index, bolus infusions of phenylephrine (bradycardia response) and sodium nitroprusside (tachycardia response) were administered.Results: Obesity resulted in dysfunctional tachycardia responses at 3 months of age. At 6 and 15 months of age, both bradycardia and tachycardia responses were significantly lower in obese animals than those in lean animals. At 15 months of age, interactions among obesity, SD and aging produced the most marked effects on the cardiovascular system (increased mean arterial pressure and heart rate and decreased baroreflex sensitivity).Conclusions: Therefore, these results suggest that there is no direct relationship between baroreflex imbalance and an increase in arterial pressure.
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 98/14303-3
Date 2013-03-01
Published in Obesity. Hoboken: Wiley-Blackwell, v. 21, n. 3, p. 510-515, 2013.
ISSN 1930-7381 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 510-515
Origin http://dx.doi.org/10.1002/oby.20063
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000322087600038
URI http://repositorio.unifesp.br/handle/11600/35988

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account