Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia

Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia

Author Siviero-Miachon, Adriana Aparecida Autor UNIFESP Google Scholar
Spinola-Castro, Angela Maria Autor UNIFESP Google Scholar
Lee, Maria Lucia de Martino Google Scholar
Andreoni, Solange Autor UNIFESP Google Scholar
Geloneze, Bruno Google Scholar
Lederman, Henrique Autor UNIFESP Google Scholar
Guerra-Junior, Gil Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract Background: Advances in treatment of acute lymphocytic leukemia increased the likelihood of developing late treatment-associated effects, such as abdominal adiposity, increasing the risk of cardiovascular disease in this population. Cranial radiotherapy is one of the factors that might be involved in this process. the aim of this study was to determine the effect of cranial radiotherapy on adiposity indexes in survivors of acute lymphocytic leukemia.Methods: A comparative cross-sectional study of 56 acute lymphocytic leukemia survivors, chronological age between 15 and 24 years, assigned into two groups according to the exposure to cranial radiotherapy (25 irradiated and 31 non-irradiated), assessed according to body fat (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, and insulin resistance.Results: Cranial radiotherapy increased body fat and abdominal adipose tissue and altered lipid panel. Yet, lipids showed no clinical relevance so far. There were significantly more obese patients among those who received cranial radiotherapy (52% irradiated versus 22.6% non-irradiated), based on dual energy X-ray absorptiometry body fat measurements. Nonetheless, no association was observed between cranial radiotherapy and body mass index, waist circumference, waist-to-height ratio or insulin resistance.Conclusions: Adolescent and young adult survivors of childhood acute lymphocytic leukemia showed an increase in body fat and an alteration of fat distribution, which were related to cranial radiotherapy. Fat compartment modifications possibly indicate a disease of adipose tissue, and cranial radiotherapy imports in this process.
Keywords Precursor cell lymphoblastic leukemia-lymphoma/radiotherapy
Abdominal fat
Lipid metabolism disorders
Insulin resistance
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 06/06162-9
Date 2013-02-21
Published in Radiation Oncology. London: Biomed Central Ltd, v. 8, 9 p., 2013.
ISSN 1748-717X (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 9
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000317786800001

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