A 6-month randomized controlled trial to test the efficacy of a lifestyle intervention for weight gain management in schizophrenia

A 6-month randomized controlled trial to test the efficacy of a lifestyle intervention for weight gain management in schizophrenia

Author Attux, Cecilia Autor UNIFESP Google Scholar
Martini, Larissa Campagna Autor UNIFESP Google Scholar
Elkis, Helio Google Scholar
Tamai, Sergio Google Scholar
Freirias, Andrea Google Scholar
Camargo, Maria das Gracas Miquelutti Google Scholar
Mateus, Mário Dinis Autor UNIFESP Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Reis, Andre Fernandes Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
CAISM Ctr Atencao Integrada Saude Mental Irmandad
Abstract Background: Patients with schizophrenia have lower longevity than the general population as a consequence of a combination of risk factors connected to the disease, lifestyle and the use of medications, which are related to weight gain.Methods: A multicentric, randomized, controlled-trial was conducted to test the efficacy of a 12-week group Lifestyle Wellness Program (LWP). the program consists of a one-hour weekly session to discuss topics like dietary choices, lifestyle, physical activity and self-esteem with patients and their relatives. Patients were randomized into two groups: standard care (SC) and standard care plus intervention (LWP). Primary outcome was defined as the weight and body mass index (BMI).Results: 160 patients participated in the study (81 in the intervention group and 79 in the SC group). On an intent to treat analysis, after three months the patients in the intervention group presented a decrease of 0.48 kg (CI 95% - 0.65 to 1.13) while the standard care group showed an increase of 0.48 kg (CI 95% 0.13 to 0.83; p=0.055). At six-month follow-up, there was a significant weight decrease of -1.15 kg, (CI 95% -2.11 to 0.19) in the intervention group compared to a weight increase in the standard care group (+0.5 kg, CI 95% -0.42-1.42, p=0.017).Conclusion: in conclusion, this was a multicentric randomized clinical trial with a lifestyle intervention for individuals with schizophrenia, where the intervention group maintained weight and presented a tendency to decrease weight after 6 months. It is reasonable to suppose that lifestyle interventions may be important long-term strategies to avoid the tendency of these individuals to increase weight. Clinicaltrials.gov identifier: NCT01368406
Keywords Schizophrenia
Clinical trial
Weight gain
Physical activity
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Eli Lilly do Brasil
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Ministry of Education
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao Safra
Fundacao ABRADS
Eli Lilly laboratory
Grant number FAPESP: 2007/00464-6
Date 2013-02-18
Published in Bmc Psychiatry. London: Biomed Central Ltd, v. 13, 9 p., 2013.
ISSN 1471-244X (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 9
Origin http://dx.doi.org/10.1186/1471-244X-13-60
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316269000001
URI http://repositorio.unifesp.br/handle/11600/35977

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