Sleep disorders in Machado-Joseph disease: A dopamine transporter imaging study

Sleep disorders in Machado-Joseph disease: A dopamine transporter imaging study

Author Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Braga-Neto, Pedro Autor UNIFESP Google Scholar
Felicio, Andre C. Autor UNIFESP Google Scholar
Minett, Thais Autor UNIFESP Google Scholar
Yamaguchi, Elton Autor UNIFESP Google Scholar
Prado, Lucila Bizari Fernandes do Autor UNIFESP Google Scholar
Carvalho, Luciane Bizari C. Autor UNIFESP Google Scholar
Dutra, Livia Almeida Autor UNIFESP Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Rocha, Antonio Jose da Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Prado, Gilmar Fernandes do Autor UNIFESP Google Scholar
Barsottini, Orlando Graziani Povoas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Santa Casa de Misericordia São Paulo
Abstract Objectives: Sleep disorders, especially restless legs syndrome (RLS) and rapid eye movement sleep behavior disorder (RBD), are common in spinocerebellar ataxia type 3 or Machado-Joseph disease (MJD), and a possible underlying dopaminergic dysfunction is implicated. This study assessed the relationship between sleep disorders in MJD and dopamine transporter (DAT) densities.Patients and methods: Twenty-two patients with MJD and twenty healthy subjects were enrolled in this study. MJD patients underwent clinical sleep evaluation and polysomnography. SPED' with [Tc-99m]-TRODAT-1, was performed in all subjects.Results: DAT densities were significantly reduced in MJD group when compared to controls. No significant correlation was found between DAT densities and RLS or RBD in MJD.Conclusion: Our study failed to demonstrate a clear correlation between sleep disorders and DAT densities in MJD patients, hence suggesting that extrastriatal and non-presynaptic dopamine pathways could be implicated in MJD-related sleep disorders. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Spinocerebellar ataxia type 3
Machado-Joseph disease
Sleep disorders
Dopamine transporter
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2013-01-15
Published in Journal of the Neurological Sciences. Amsterdam: Elsevier B.V., v. 324, n. 1-2, p. 90-93, 2013.
ISSN 0022-510X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 90-93
Access rights Closed access
Type Article
Web of Science ID WOS:000314855500019

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