Lipid profiling of follicular fluid from women undergoing IVF: Young poor ovarian responders versus normal responders

Lipid profiling of follicular fluid from women undergoing IVF: Young poor ovarian responders versus normal responders

Author Cataldi, Thais Autor UNIFESP Google Scholar
Cordeiro, Fernanda Bertuccez Autor UNIFESP Google Scholar
Teixeira da Costa, Livia Do Vale Autor UNIFESP Google Scholar
Pilau, Eduardo Jorge Google Scholar
Ferreira, Christina Ramires Google Scholar
Gozzo, Fabio Cesar Google Scholar
Eberlin, Marcos Nogueira Google Scholar
Bertolla, Ricardo Pimenta Autor UNIFESP Google Scholar
Cedenho, Agnaldo Pereira Autor UNIFESP Google Scholar
Lo Turco, Edson Guimaraes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Jardim Univ Maringa
Abstract This study identified possible lipid biomarkers in follicular fluid from women with poor ovarian response. These biomarkers indicate pathophysiological pathways and have potential diagnostic applications. An observational case-control study of young women undergoing ovarian stimulation for in-vitro fertilization was conducted. the participants were categorized into a poor ovarian response group and a normal ovarian response to stimulation group. All of the women underwent the same ovarian stimulation protocol, and follicular fluid was collected after ovarian aspiration. Analyses were performed using matrix-assisted laser desorption/ionization mass spectrometry. Principal component analysis and Volcano plots were used to describe follicular fluid classification models based on the lipid profiles. A total of 10 lipids were differentially expressed between the study and control groups. of these lipid ions, three belonged to the phosphatidylcholine subclass and were present in higher concentrations in the control group. the other seven differential lipids were present in the study group and classified into four lipid subclasses: phosphatidylethanolamines, phosphatidylglycerols, phosphatidylinositols, and diacylglycerols. These distinctive lipids may be involved in hormonal responses and oocyte development processes and may be useful as biomarkers for therapeutic intervention in women with poor ovarian response.
Keywords Poor ovarian response
in-vitro fertilization
follicular fluid
lipidomics
MALDI-MS
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-01-01
Published in Human Fertility. New York: Informa Healthcare, v. 16, n. 4, p. 269-277, 2013.
ISSN 1464-7273 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 269-277
Origin http://dx.doi.org/10.3109/14647273.2013.852255
Access rights Closed access
Type Article
Web of Science ID WOS:000328283000008
URI http://repositorio.unifesp.br/handle/11600/35860

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