Dyslipidemia in Pediatric Systemic Lupus Erythematosus: the Relationship with Disease Activity and Plasma Homocysteine and Cysteine Concentrations

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dc.contributor.author Ortiz, Thais Tobaruela [UNIFESP]
dc.contributor.author Terreri, Maria Teresa [UNIFESP]
dc.contributor.author Caetano, Michelle [UNIFESP]
dc.contributor.author Souza, Fabiola Suano [UNIFESP]
dc.contributor.author D'Almeida, Vania [UNIFESP]
dc.contributor.author Sarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.author Esteves Hilario, Maria Odete [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:06Z
dc.date.available 2016-01-24T14:31:06Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.1159/000351076
dc.identifier.citation Annals of Nutrition and Metabolism. Basel: Karger, v. 63, n. 1-2, p. 77-82, 2013.
dc.identifier.issn 0250-6807
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35849
dc.description.abstract Objective: To evaluate the presence of dyslipidemia and plasma concentrations of homocysteine (Hcy) and cysteine (Cys) in adolescents with juvenile systemic lupus erythematosus (SLE) and relate these findings to disease activity (Systemic Lupus Erythematosus Disease Activity Index, SLEDAI) and cardiovascular risk factors. Methods: A cross-sectional controlled study including 26 female adolescents with SLE and 26 healthy controls was conducted. We evaluated SLEDAI, medications, anthropometric data, dietary intake, lipid profile, proteinuria, Hcy, Cys, folic acid, vitamin B-12, and high-sensitivity C-reactive protein levels. Results: Dyslipidemia was observed in 46.2% of the patients and in 19.2% of the controls. the SLE group had a higher Cys concentration and a lower high-density lipoprotein cholesterol concentration compared with the controls. in the multivariate analysis only Hcy was significantly and independently associated with the presence of dyslipidemia in the juvenile SLE group; an increase of 1 mu mol/l in the Hcy concentration doubled the chance of dyslipidemia (OR: 2.1; 95% Cl: 1.1-4.9; p = 0.030). the Cys concentration was correlated with Hcy, total cholesterol, low-density lipoprotein cholesterol, and triglyceride concentrations. Conclusion: We observed the presence of cardiovascular risk factors in adolescents with juvenile SLE. the early identification of biochemical alterations allows the development of intervention strategies that may lower the risk of cardiovascular disease. Copyright (C) 2013 S. Karger AG, Basel en
dc.format.extent 77-82
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Annals of Nutrition and Metabolism
dc.rights Acesso restrito
dc.subject Systemic lupus erythematosus en
dc.subject Dyslipidemia en
dc.subject Adolescents en
dc.subject Homocysteine en
dc.subject Cysteine en
dc.title Dyslipidemia in Pediatric Systemic Lupus Erythematosus: the Relationship with Disease Activity and Plasma Homocysteine and Cysteine Concentrations en
dc.type Artigo
dc.rights.license http://www.karger.com/Services/RightsPermissions
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.identifier.doi 10.1159/000351076
dc.description.source Web of Science
dc.identifier.wos WOS:000325385800011



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