Dyslipidemia in Pediatric Systemic Lupus Erythematosus: the Relationship with Disease Activity and Plasma Homocysteine and Cysteine Concentrations

Dyslipidemia in Pediatric Systemic Lupus Erythematosus: the Relationship with Disease Activity and Plasma Homocysteine and Cysteine Concentrations

Author Ortiz, Thais Tobaruela Autor UNIFESP Google Scholar
Terreri, Maria Teresa Autor UNIFESP Google Scholar
Caetano, Michelle Autor UNIFESP Google Scholar
Souza, Fabiola Suano Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Sarni, Roseli Oselka Saccardo Autor UNIFESP Google Scholar
Esteves Hilario, Maria Odete Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To evaluate the presence of dyslipidemia and plasma concentrations of homocysteine (Hcy) and cysteine (Cys) in adolescents with juvenile systemic lupus erythematosus (SLE) and relate these findings to disease activity (Systemic Lupus Erythematosus Disease Activity Index, SLEDAI) and cardiovascular risk factors. Methods: A cross-sectional controlled study including 26 female adolescents with SLE and 26 healthy controls was conducted. We evaluated SLEDAI, medications, anthropometric data, dietary intake, lipid profile, proteinuria, Hcy, Cys, folic acid, vitamin B-12, and high-sensitivity C-reactive protein levels. Results: Dyslipidemia was observed in 46.2% of the patients and in 19.2% of the controls. the SLE group had a higher Cys concentration and a lower high-density lipoprotein cholesterol concentration compared with the controls. in the multivariate analysis only Hcy was significantly and independently associated with the presence of dyslipidemia in the juvenile SLE group; an increase of 1 mu mol/l in the Hcy concentration doubled the chance of dyslipidemia (OR: 2.1; 95% Cl: 1.1-4.9; p = 0.030). the Cys concentration was correlated with Hcy, total cholesterol, low-density lipoprotein cholesterol, and triglyceride concentrations. Conclusion: We observed the presence of cardiovascular risk factors in adolescents with juvenile SLE. the early identification of biochemical alterations allows the development of intervention strategies that may lower the risk of cardiovascular disease. Copyright (C) 2013 S. Karger AG, Basel
Keywords Systemic lupus erythematosus
Dyslipidemia
Adolescents
Homocysteine
Cysteine
Language English
Date 2013-01-01
Published in Annals of Nutrition and Metabolism. Basel: Karger, v. 63, n. 1-2, p. 77-82, 2013.
ISSN 0250-6807 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 77-82
Origin http://dx.doi.org/10.1159/000351076
Access rights Closed access
Type Article
Web of Science ID WOS:000325385800011
URI http://repositorio.unifesp.br/handle/11600/35849

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account