Sleep deprivation alters phosphorylated CREB levels in the amygdala: Relationship with performance in a fear conditioning task

Sleep deprivation alters phosphorylated CREB levels in the amygdala: Relationship with performance in a fear conditioning task

Author Pinho, Nadine Autor UNIFESP Google Scholar
Moreira, Karin Monteiro Autor UNIFESP Google Scholar
Hipólide, Débora Cristina Autor UNIFESP Google Scholar
Sinigaglia-Coimbra, Rita Autor UNIFESP Google Scholar
Ferreira, Tatiana Lima Google Scholar
Nobrega, Jose N. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Menezes Oliveira, Maria Gabriela Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Ctr Addict & Mental Hlth
Abstract We investigated the relationship between deficits in fear memory induced by sleep deprivation and pCREB expression in the basal and central nuclei of the amygdala. Sleep deprivation reduced pCREB expression in the central nucleus compared to control or sleep recovered groups, and in the basal nucleus only compared to sleep recovered group. Moreover, 24 h of sleep recovery prior to training prevented changes in both pCREB expression and performance. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Memory
Sleep
CREB
Amygdala
Contextual fear conditioning
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2013-01-01
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 236, p. 221-224, 2013.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 221-224
Origin http://dx.doi.org/10.1016/j.bbr.2012.08.043
Access rights Closed access
Type Article
Web of Science ID WOS:000310929400028
URI http://repositorio.unifesp.br/handle/11600/35797

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