Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance

Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance

Author Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Siegfried, Wolfgang Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Silva, Patricia Leao da Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Dantas, Alexandre Dâmaso Aguilera Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Obes Rehabil Ctr INSULA
Weight Sci
Abstract The prevention of obesity and health concerns related to body fat is a major challenge worldwide. the aim of this study was to investigate the role of a medically supervised, multidisciplinary approach, on reduction in the prevalence of obesity related comorbidities, inflammatory profile, and neuroendocrine regulation of energy balance in a sample of obese adolescents. A total of 97 postpuberty obese adolescents were enrolled in this study. Body composition, neuropeptides, and adipokines were analysed. the metabolic syndrome was defined by the International Diabetes Federation (IDF). the abdominal ultrasonography was performed to measure visceral, subcutaneous fat and hepatic steatosis. All measures were performed at baseline and after one year of therapy. the multidisciplinary management promoted the control of obesity reducing body fat mass. the prevalence of metabolic syndrome, asthma, nonalcoholic fatty liver disease (NAFLD), binge eating, and hyperleptinemia was reduced. An improvement in the inflammatory profile was demonstrated by an increase in anti-inflammatory adiponectin and reduction in proinflammatory adipokines, plasminogen activator inhibitor-1, interleukin-6 concentrations, and in the Lep/Adipo ratio. Moreover, a reduction in the AgRP and an increase in the alfa-MSH were noted. the multidisciplinary approach not only reduced obesity but also is efficacious in cardiovascular risk factors, inflammatory profile, and neuroendocrine regulation of energy balance.
Language English
Sponsor CEPE
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
FADA
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Universidade Federal de São Paulo
Grant number FAPESP: 2006/00684-3
FAPESP: 2008/53069-0
FAPESP: 2011/503560
FAPESP: 2011/50414-0
FAPESP: 9814303-3
CAPES: 2566/2011
Date 2013-01-01
Published in International Journal of Endocrinology. New York: Hindawi Publishing Corporation, 10 p., 2013.
ISSN 1687-8337 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 10
Origin https://dx.doi.org/10.1155/2013/541032
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000326751600001
URI https://repositorio.unifesp.br/handle/11600/35696

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