Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis

Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis

Author Bernardo, Wanderley Marques Google Scholar
Aires, Felipe Toyama Google Scholar
Carneiro, Renata Mota Google Scholar
Sá, Fernando Pereira de Google Scholar
Rullo, Vera Esteves Vagnozzi Autor UNIFESP Google Scholar
Burns, Dennis Alexander Google Scholar
Institution Assoc Med Brasileira
Conselho Fed Med
Fac Ciencias Med Santos UNILUS
UNILUS
Soc Brasileira Pediat
Universidade Federal de São Paulo (UNIFESP)
Soc Pediat Dist Fed
Abstract Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns.Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) and (probiotics).Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p < 0.001) and hospitalization time (p < 0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC.Conclusion: in premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
Keywords Necrotizing enterocolitis
Probiotics
Premature
Language English
Date 2013-01-01
Published in Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 89, n. 1, p. 18-24, 2013.
ISSN 0021-7557 (Sherpa/Romeo, impact factor)
Publisher Soc Brasil Pediatria
Extent 18-24
Origin http://dx.doi.org/10.1016/j.jped.2013.02.004
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000316163600004
SciELO ID S0021-75572013000100004 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/35650

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