Safety and efficacy analysis of liposomal insulin-like growth factor-1 in a fluid gel formulation for hair-loss treatment in a hamster model

Safety and efficacy analysis of liposomal insulin-like growth factor-1 in a fluid gel formulation for hair-loss treatment in a hamster model

Author Castro, R. F. Google Scholar
Azzalis, L. A. Autor UNIFESP Google Scholar
Feder, D. Google Scholar
Perazzo, F. F. Autor UNIFESP Google Scholar
Pereira, E. C. Autor UNIFESP Google Scholar
Junqueira, V. B. C. Autor UNIFESP Google Scholar
Rocha, K. C. Google Scholar
Machado, C. D'A Google Scholar
Paschoal, F. C. Google Scholar
Gnann, L. A. Google Scholar
Fonseca, F. L. A. Autor UNIFESP Google Scholar
Institution Fac Med ABC
Universidade Federal de São Paulo (UNIFESP)
Abstract Insulin-like growth factor (IGF)-1 has shown some interesting results in studies examining its use as a hair-loss treatment. IGF-1 works by regulating cellular proliferation and migration during the development of hair follicles. Hepatotoxicity and myelotoxicity were evaluated in hamsters (Mesocricetus auratus) after topical application of the liquid gel vehicle (placebo), 1% IGF-1 or 3% IGF-1. No significant difference in the levels of aspartate aminotransferase or alanine aminotransferase was found between the control and treated groups. ELISA did not shown any increase in the plasma level of IGF-1. A haematopoietic niche was found, but it was not associated with myelotoxicity. Efficacy was determined by dermatoscopy analysis of hair density and microscopy analysis of hair diameter, with hair found to be thicker and with more rapid growth in the 3% group than in either the 1% group or the control group. These results strongly suggest that liposomal IGF-1 in a liquid gel formulation is a safe and efficient treatment for hair loss.
Language English
Date 2012-12-01
Published in Clinical and Experimental Dermatology. Hoboken: Wiley-Blackwell, v. 37, n. 8, p. 909-912, 2012.
ISSN 0307-6938 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 909-912
Origin http://dx.doi.org/10.1111/j.1365-2230.2012.04441.x
Access rights Closed access
Type Article
Web of Science ID WOS:000311408200016
URI http://repositorio.unifesp.br/handle/11600/35591

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