Experimental Video Analysis of Eye Blink Reflex in a Primate Model

Experimental Video Analysis of Eye Blink Reflex in a Primate Model

Author Borin, Andrei Autor UNIFESP Google Scholar
Mello, Luiz Eugenio Araujo M. Autor UNIFESP Google Scholar
Neiva, Felipe Costa Autor UNIFESP Google Scholar
Gurgel Testa, Jose Ricardo Autor UNIFESP Google Scholar
Mendonca Cruz, Oswaldo Laercio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: the establishment of reliable methods for functional assessment in experimental models of peripheral nerve regeneration is crucial.Methods: We present a straightforward method for video analysis of the eye blink reflex in a model of facial nerve damage in a nonhuman primate (Callithrix sp.).Results: Our 6-level dynamic analysis demonstrated good reproducibility between independent observers, as measured by Cohen's kappa index. Our static analysis, which was based on 4 semi-automated metric parameters, showed low correlation during the early stage of facial movement recovery (the first and second weeks), but the correlation was excellent during the later stage of recovery (the third and fourth weeks).Conclusion: Altogether, our results establish a viable and readily accessible method with good reproducibility and correlation for the analysis of functional facial nerve recovery in an experimental model and based on video images of the eye blink reflex.
Keywords Facial nerve
Facial paralysis
Nerve regeneration
Primates
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2009/52805-7
Date 2012-12-01
Published in Otology & Neurotology. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 9, p. 1625-1629, 2012.
ISSN 1531-7129 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1625-1629
Origin http://dx.doi.org/10.1097/MAO.0b013e31826939e4
Access rights Closed access
Type Article
Web of Science ID WOS:000311214500034
URI http://repositorio.unifesp.br/handle/11600/35588

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