DRD1 rs4532 polymorphism: A potential pharmacogenomic marker for treatment response to antipsychotic drugs

DRD1 rs4532 polymorphism: A potential pharmacogenomic marker for treatment response to antipsychotic drugs

Author Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Spindola, Leticia Nery Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Santos Filho, Airton Ferreira dos Autor UNIFESP Google Scholar
Santoro, Marcos Leite Autor UNIFESP Google Scholar
Christofolini, Denise Maria Google Scholar
Bellucco, Fernanda Teixeira Autor UNIFESP Google Scholar
Ribeiro-dos-Santos, Andrea Kely Google Scholar
Santos, Sidney Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Melaragno, Maria Isabel Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Cardoso Smith, Marilia de Arruda Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC FMABC
Universidade Federal do Pará (UFPA)
Abstract We investigated the association of dopamine receptor D1 gene (DRD1) rs4532 polymorphism with antipsychotic treatment response in schizophrenia. We have analyzed 124 patients with schizophrenia, consisting of 59 treatment resistant (TR) and 65 non-TR. We found an association between G-allele and TR schizophrenia (p=0.001; adjusted OR=2.71). Setting the common AA-genotype as reference, the GG-homozygous presented a five-fold risk compared to AA-homozygous (p=0.010; OR=5.56) with an intermediate result for AG-genotype (p=0.030; adjusted OR=2.64). the DRD1 rs4532 polymorphism showed a dose-response gradient with increased risk for treatment resistance and may be a potential pharmacogenetic marker for antipsychotic drug treatment response. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Schizophrenia
DRD1
Pharmacogenomics
Treatment-resistant
Antipsycotic
Dopamine
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: FAPESP 2007/58736-1
FAPESP: 2011/00030-1
Date 2012-12-01
Published in Schizophrenia Research. Amsterdam: Elsevier B.V., v. 142, n. 1-3, p. 206-208, 2012.
ISSN 0920-9964 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 206-208
Origin http://dx.doi.org/10.1016/j.schres.2012.08.003
Access rights Closed access
Type Article
Web of Science ID WOS:000311220900031
URI http://repositorio.unifesp.br/handle/11600/35574

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