Vesicles as carriers of virulence factors in parasitic protozoan diseases

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dc.contributor.author Torrecilhas, Ana Claudia [UNIFESP]
dc.contributor.author Schumacher, Robert I.
dc.contributor.author Alves, Maria Julia M.
dc.contributor.author Colli, Walter
dc.date.accessioned 2016-01-24T14:28:06Z
dc.date.available 2016-01-24T14:28:06Z
dc.date.issued 2012-12-01
dc.identifier http://dx.doi.org/10.1016/j.micinf.2012.07.008
dc.identifier.citation Microbes and Infection. Amsterdam: Elsevier B.V., v. 14, n. 15, p. 1465-1474, 2012.
dc.identifier.issn 1286-4579
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35569
dc.description.abstract Different types of shed vesicles as, for example, exosomes, plasma-membrane-derived vesicles or microparticles, are the focus of intense research in view of their potential role in cell cell communication and under the perspective that they might be good tools for immunotherapy, vaccination or diagnostic purposes. This review discusses ways employed by pathogenic trypanosomatids to interact with the host by shedding vesicles that contain molecules important for the establishment of infection, as opposed to previous beliefs considering them as a waste of cellular metabolism. Trypanosomatids are compared with Apicomplexa, which circulate parasite antigens bound to vesicles shed by host cells. the knowledge of the origin and chemical composition of these different vesicles might lead to the understanding of the mechanisms that determine their biological function. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 1465-1474
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Microbes and Infection
dc.rights Acesso restrito
dc.subject Pathogenic protozoan parasites en
dc.subject Vesicles en
dc.subject Virulence factors en
dc.title Vesicles as carriers of virulence factors in parasitic protozoan diseases en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Ciencias Biol, UNIFESP, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Inst Quim, Dept Bioquim, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ciencias Biol, UNIFESP, São Paulo, Brazil
dc.identifier.doi 10.1016/j.micinf.2012.07.008
dc.description.source Web of Science
dc.identifier.wos WOS:000313151600011



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