Analysis of Risk Factors for Extubation Failure in Subjects Submitted to Non-Emergency Elective Intracranial Surgery

Analysis of Risk Factors for Extubation Failure in Subjects Submitted to Non-Emergency Elective Intracranial Surgery

Author Vidotto, Milena Carlos Autor UNIFESP Google Scholar
Sogame, Luciana Carrupt Machado Autor UNIFESP Google Scholar
Gazzotti, Mariana Rodrigues Autor UNIFESP Google Scholar
Prandini, Mirto Nelson Autor UNIFESP Google Scholar
Jardim, Jose Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Escola Super Ciencias Santa Casa Misericordia Vit
Abstract BACKGROUND: Extubation failure is defined as the re-institution of respiratory support ranging from 24 to 72 hours following scheduled extubation and occurs in 2% to 25% of extubated patients. the aim of this study was to determine clinical and surgical risk factors that may predict extubation failure in patients submitted to non-emergency intracranial surgery. METHODS: This was a prospective observational cohort study. the study was carried out on 317 subjects submitted to non-emergency intracranial surgery for tumors, aneurysms, and arteriovenous malformation. Preoperative assessment was performed and subjects were followed up for the determination of extubation failure until either discharge from hospital or death. RESULTS: Twenty-six (8.2%) of the 317 subjects experienced extubation failure following surgery. the following variables were considered for the multivariate analysis: level of consciousness at the time of extubation, duration of mechanical ventilation prior to extubation, sex and the use of intraoperative mannitol. the multivariate analysis determined that the most important variable for extubation failure was the level of consciousness at the time of extubation (P = .001), followed by female sex, which also showed to be significant (P = .006). CONCLUSIONS: Lower level of consciousness (GCS 8T-10T) and female sex were considered risk factors for extubation failure in subjects submitted to elective intracranial surgery.
Keywords neurosurgery
craniotomy
ventilator weaning
intratracheal intubation
risk factors
postoperative period
Language English
Date 2012-12-01
Published in Respiratory Care. Irving: Daedalus Enterprises Inc, v. 57, n. 12, p. 2059-2066, 2012.
ISSN 0020-1324 (Sherpa/Romeo, impact factor)
Publisher Daedalus Enterprises Inc
Extent 2059-2066
Origin http://rc.rcjournal.com/content/57/12/2059.short
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000312057300010
URI http://repositorio.unifesp.br/handle/11600/35537

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