Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates

Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates

Author Neiva, Felipe Costa Autor UNIFESP Google Scholar
Borin, Andrei Autor UNIFESP Google Scholar
Cinini, Simone Autor UNIFESP Google Scholar
Mello, Luiz Eugenio A. M. Autor UNIFESP Google Scholar
Cruz, Oswaldo Laercio M. Autor UNIFESP Google Scholar
Testa, Jose Ricardo G. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Conclusion: We conclude that facial nerve injury induced by compression is associated with a reasonable time window (4 weeks) that allows possible neurotrophic effects to be analyzed. Additionally, there are no hints of cross-innervation by the contralateral facial nerve or parallel innervation by other nerves in the hemiface ipsilateral to the injured nerve. Objective: the aim of this work was to develop an experimental model of facial nerve injury in nonhuman primates (Callithrix sp.). Methods: in this study, individuals of the non-human primate species Callithrix sp. were subjected to three different types of facial nerve injury, and they were observed for 27 days after surgery by video to record their facial movements. Results: Two types of nerve compression caused severe initial facial paralysis followed by gradual recovery until normal levels were reached at the end of the evaluation period. Injury induced by nerve resection was followed by a complete lack of facial movement recovery.
Keywords Facial nerve
nerve regeneration
animal models
neurology
cranial nerve diseases
cranial nerves
nerve degeneration
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: FAPESP 2009/52805-7
Date 2012-11-01
Published in Acta Oto-laryngologica. London: Informa Healthcare, v. 132, n. 11, p. 1239-1242, 2012.
ISSN 0001-6489 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 1239-1242
Origin http://dx.doi.org/10.3109/00016489.2012.697639
Access rights Closed access
Type Article
Web of Science ID WOS:000309751800017
URI http://repositorio.unifesp.br/handle/11600/35492

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