Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers

Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers

Author Monteiro, Andrea M. Google Scholar
Jardini, Maria A. N. Google Scholar
Giampaoli, Viviana Google Scholar
Alves, Sarah Autor UNIFESP Google Scholar
Figueiredo Neto, Antonio M. Google Scholar
Gidlund, Magnus Google Scholar
Institution Universidade de São Paulo (USP)
São Paulo State Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract The Z-Scan (ZS) technique in the thermal regime has been used to measure the nonlinear optical response of low-density lipoprotein (LDL). the ZS technique is carried out in LDL from 40 patients with chronic periodontitis before and after three, six, and 12 months of periodontal treatment. Clinical parameters such as probing depths, bleeding on probing, total and differential white blood cells counts, lipid profiles, cytokine levels, and antibodies against oxidized LDL are also determined and compared over time. Before the treatment, the ZS experimental results reveal that the LDL particles of these patients are heavily modified. Only after 12 months of the periodontal treatment, the ZS results obtained reveal behavioral characteristics of healthy particles. This conclusion is also supported by complementary laboratorial analysis showing that the periodontal treatment induces systemic changes in several inflammatory markers. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.11.115004]
Keywords Z-scan
nonlinear
atherosclerosis
inflammation
oral health
oxLDL
periodontitis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
INCT-FCX
INCT-INAMI
Date 2012-11-01
Published in Journal of Biomedical Optics. Bellingham: Spie-soc Photo-optical Instrumentation Engineers, v. 17, n. 11, 7 p., 2012.
ISSN 1083-3668 (Sherpa/Romeo, impact factor)
Publisher Spie-soc Photo-optical Instrumentation Engineers
Extent 7
Origin http://dx.doi.org/10.1117/1.JBO.17.11.115004
Access rights Closed access
Type Article
Web of Science ID WOS:000314502700011
URI http://repositorio.unifesp.br/handle/11600/35491

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