A 12-wk follow-up study to evaluate the effects of mixing insulin lispro and insulin glargine in young individuals with type 1 diabetes

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dc.contributor.author Lucchesi, Maria B. B. [UNIFESP]
dc.contributor.author Komatsu, William R. [UNIFESP]
dc.contributor.author Gabbay, Monica Andrade Lima [UNIFESP]
dc.contributor.author Dib, Sergio A. [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:59Z
dc.date.available 2016-01-24T14:27:59Z
dc.date.issued 2012-11-01
dc.identifier http://dx.doi.org/10.1111/j.1399-5448.2012.00867.x
dc.identifier.citation Pediatric Diabetes. Hoboken: Wiley-Blackwell, v. 13, n. 7, p. 519-524, 2012.
dc.identifier.issn 1399-543X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35485
dc.description.abstract Objective: This study was performed to compare in real-life conditions the serum profile of insulin lispro (IL) after a subcutaneous (SC) injection, separate and mixed with insulin glargine (IG), using a sensitive radioimmunoassay for the specific determination of serum IL, and to evaluate the 12-wk effect of the mixture on glycemic control in young individuals with type 1 diabetes.Research design and methods: the IL serum profiles were evaluated in 10 individuals with type 1 diabetes [age 21.9 +/- 3.8 yr; diabetes duration 13.4 +/- 4.9 yr; body mass index 25.1 +/- 3.2 kg/m(2); hemoglobin A1c (HbA1c) 8.3 +/- 0.8%] during a mixed meal test (MMT) using IL and IG as separate (baseline) and mixed injection. the glycemic variability by continuous glucose monitoring system (CGMS) and the long-term diabetes control with HbA1c were also evaluated at baseline and after 12 wk mixing the two insulins.Results: the mixture of IL with IG decreased IL maximum serum concentration (C-maxIL) (29.4 +/- 5.1 mu U/mL vs. 13.7 +/- 4.2 mu U/mL; p = 0.03) without changing the time to reach the Cmax (T-maxIL), the IL area under the curve (AUC(IL0-240)), and the glucose dynamics during the MMT. the glucose variability and the HbA1c were equivalent to baseline after 12 wk mixing both insulins.Conclusions: These data suggest that mixing IL with IG immediately before the SC injection decreases IL serum peak concentration without affecting the glycemic profile after 12 wk in this group with type 1 diabetes mellitus. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 519-524
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Pediatric Diabetes
dc.rights Acesso restrito
dc.subject glycemic variability and glucose control en
dc.subject insulin analogs en
dc.subject insulin levels en
dc.subject mixtures en
dc.title A 12-wk follow-up study to evaluate the effects of mixing insulin lispro and insulin glargine in young individuals with type 1 diabetes en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Ctr Diabet, Div Endocrinol, BR-04032001 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Ctr Diabet, Div Endocrinol, BR-04032001 São Paulo, Brazil
dc.identifier.doi 10.1111/j.1399-5448.2012.00867.x
dc.description.source Web of Science
dc.identifier.wos WOS:000310551600002



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