Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis

Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis

Author Pezato, Rogério Autor UNIFESP Google Scholar
Swierczynska-Krepa, M. Google Scholar
Nizankowska-Mogilnicka, E. Google Scholar
Derycke, L. Google Scholar
Bachert, C. Google Scholar
Perez-Novo, C. A. Google Scholar
Institution Univ Ghent
Jagiellonian Univ
Universidade Federal de São Paulo (UNIFESP)
Medex
Abstract Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosanoids) have been linked to the pathophysiology of different diseases especially nasal polyposis, asthma, and aspirin-exacerbated respiratory disease. Furthermore, viral and bacterial infections have been identified as important factors amplifying the pro-inflammatory reactions in these pathologies. This review summarizes the impact of an imbalance in the eicosanoid pathway and the effect of Staphylococcus aureus enterotoxins on the regulation of the pro-inflammatory network in CRS and their translation into disease severity.
Keywords aspirin-exacerbated respiratory disease
chronic rhinosinusitis
eicosanoids
nasal polyposis
staphylococcal enterotoxins
Language English
Sponsor Flemish Research Board (FWO Post-doctoral mandate)
European Union
São Paulo State Military Police-Health Department, Brazil
Flemish Scientific Research Board FWO
Interuniversity Attraction Poles Program
Grant number Flemish Research Board (FWO Post-doctoral mandate): FWO08-PDO-117
European Union: 17
Flemish Scientific Research Board FWO: A12/5-HB-KH3
Flemish Scientific Research Board FWO: G.0436.04
Interuniversity Attraction Poles Program: IAP P6/35
Date 2012-11-01
Published in Allergy. Hoboken: Wiley-Blackwell, v. 67, n. 11, p. 1347-1356, 2012.
ISSN 0105-4538 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1347-1356
Origin http://dx.doi.org/10.1111/all.12010
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000309715300004
URI http://repositorio.unifesp.br/handle/11600/35428

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