A strength exercise program in rats with epilepsy is protective against seizures

A strength exercise program in rats with epilepsy is protective against seizures

Author Peixinho-Pena, Luiz Fernando Autor UNIFESP Google Scholar
Fernandes, Jansen Autor UNIFESP Google Scholar
Almeida, Alexandre Aparecido de Autor UNIFESP Google Scholar
Gomes, Fabiano Guimaraes Novaes Autor UNIFESP Google Scholar
Cassilhas, Ricardo Cardoso Autor UNIFESP Google Scholar
Venancio, Daniel Paulino Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The beneficial effects of physical exercise on epilepsy, such as a decreased seizure frequency, have been observed following aerobic exercise programs in both clinical and experimental studies. However, it is not well clarified whether other types of exercise, including strength exercise, can provide similar benefits for epilepsy. Forty four animals with epilepsy were continuously monitored 24 h a day for 60 days and divided into two periods of 30 days. the first period was used to determine the number of seizures before beginning the physical exercise program, and the second period was utilized to determine the number of seizures during the strength training. the mean frequency of seizures in the control and SHAM groups increased significantly from period 1 to period 2. Although the frequency of seizures did not change significantly between the two periods of 30 days of observation in the strength exercise group, a significant reduction in the seizure frequency was observed compared with the control and SHAM groups in period 2. Our study demonstrated that a strength exercise program exerted a significant influence on the seizure frequency in animals with epilepsy and strengthens the observed beneficial effect of exercise on epilepsy that has been demonstrated in animal studies. the finding of this nonclinical study can open a new window to verify the beneficial contribution of strength exercise in epilepsy. Further experimental and clinical investigations are necessary to explore the extent to which strength exercise interferes with the epileptic condition. (c) 2012 Elsevier Inc. All rights reserved.
Keywords Exercise
Epilepsy
Pilocarpine
Seizure
Strength training
Resistance training
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
INNT (Brazil)
CInAPCe (Brazil)
Date 2012-11-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 25, n. 3, p. 323-328, 2012.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 323-328
Origin http://dx.doi.org/10.1016/j.yebeh.2012.08.011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000310917000005
URI http://repositorio.unifesp.br/handle/11600/35424

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