Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women

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dc.contributor.author Rebelo, Ana Cristina
dc.contributor.author Verlengia, Rozangela
dc.contributor.author Kunz, Vandeni
dc.contributor.author Tamburus, Nayara
dc.contributor.author Cerda, Alvaro [UNIFESP]
dc.contributor.author Hirata, Rosario [UNIFESP]
dc.contributor.author Hirata, Mario [UNIFESP]
dc.contributor.author Silva, Ester
dc.date.accessioned 2016-01-24T14:27:46Z
dc.date.available 2016-01-24T14:27:46Z
dc.date.issued 2012-10-01
dc.identifier http://dx.doi.org/10.3390/ijms131013691
dc.identifier.citation International Journal of Molecular Sciences. Basel: Mdpi Ag, v. 13, n. 10, p. 13691-13703, 2012.
dc.identifier.issn 1422-0067
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35326
dc.description.abstract This study examined the association of estrogen receptor alpha gene (ESR1) polymorphisms with cardiorespiratory and metabolic parameters in young women. in total, 354 healthy women were selected for cardiopulmonary exercise testing and short-term heart rate (HR) variability (HRV) evaluation. the HRV analysis was determined by the temporal indices rMSSD (square root of the mean squared differences of successive R-R intervals (RRi) divided by the number of RRi minus one), SDNN (root mean square of differences from mean RRi, divided by the number of RRi) and power spectrum components by low frequency (LF), high frequency (HF) and LF/HF ratio. Blood samples were obtained for serum lipids, estradiol and DNA extraction. ESR1 rs2234693 and rs9340799 polymorphisms were analyzed by PCR and fragment restriction analysis. HR and oxygen uptake (VO2) values did not differ between the ESR1 polymorphisms with respect to autonomic modulation. We not find a relationship between ESR1 T-A, T-G, C-A and C-G haplotypes and cardiorespiratory and metabolic variables. Multiple linear regression analysis demonstrated that VO2, total cholesterol and triglycerides influence HRV (p < 0.05). the results suggest that ESR1 variants have no effect on cardiorespiratory and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in healthy women. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship CONICYT-Chile
dc.format.extent 13691-13703
dc.language.iso eng
dc.publisher Mdpi Ag
dc.relation.ispartof International Journal of Molecular Sciences
dc.rights Acesso aberto
dc.subject estrogen receptor-alpha gene polymorphisms en
dc.subject heart rate variability en
dc.subject aerobic capacity en
dc.subject lipids en
dc.title Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women en
dc.type Artigo
dc.contributor.institution Universidade Federal de Goiás (UFG)
dc.contributor.institution Univ Metodista Piracicaba
dc.contributor.institution Adventist Univ Ctr São Paulo
dc.contributor.institution Universidade Federal de São Carlos (UFSCar)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Goias, Dept Morphol, BR-74001970 Goiania, Go, Brazil
dc.description.affiliation Univ Metodista Piracicaba, Coll Hlth Sci, BR-13400911 Piracicaba, SP, Brazil
dc.description.affiliation Adventist Univ Ctr São Paulo, BR-13165970 Engenheiro Coellho, SP, Brazil
dc.description.affiliation Univ Fed Sao Carlos, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Lab Appl Mol Biol & Pharmacogen, BR-58005508 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Lab Appl Mol Biol & Pharmacogen, BR-58005508 São Paulo, Brazil
dc.description.sponsorshipID CNPq: 370448/2007-3
dc.description.sponsorshipID FAPESP: 2006/56788-1
dc.identifier.file WOS000310677800086.pdf
dc.identifier.doi 10.3390/ijms131013691
dc.description.source Web of Science
dc.identifier.wos WOS:000310677800086



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