Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women

Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women

Author Rebelo, Ana Cristina Google Scholar
Verlengia, Rozangela Google Scholar
Kunz, Vandeni Google Scholar
Tamburus, Nayara Google Scholar
Cerda, Alvaro Autor UNIFESP Google Scholar
Hirata, Rosario Autor UNIFESP Google Scholar
Hirata, Mario Autor UNIFESP Google Scholar
Silva, Ester Google Scholar
Institution Universidade Federal de Goiás (UFG)
Univ Metodista Piracicaba
Adventist Univ Ctr São Paulo
Universidade Federal de São Carlos (UFSCar)
Universidade Federal de São Paulo (UNIFESP)
Abstract This study examined the association of estrogen receptor alpha gene (ESR1) polymorphisms with cardiorespiratory and metabolic parameters in young women. in total, 354 healthy women were selected for cardiopulmonary exercise testing and short-term heart rate (HR) variability (HRV) evaluation. the HRV analysis was determined by the temporal indices rMSSD (square root of the mean squared differences of successive R-R intervals (RRi) divided by the number of RRi minus one), SDNN (root mean square of differences from mean RRi, divided by the number of RRi) and power spectrum components by low frequency (LF), high frequency (HF) and LF/HF ratio. Blood samples were obtained for serum lipids, estradiol and DNA extraction. ESR1 rs2234693 and rs9340799 polymorphisms were analyzed by PCR and fragment restriction analysis. HR and oxygen uptake (VO2) values did not differ between the ESR1 polymorphisms with respect to autonomic modulation. We not find a relationship between ESR1 T-A, T-G, C-A and C-G haplotypes and cardiorespiratory and metabolic variables. Multiple linear regression analysis demonstrated that VO2, total cholesterol and triglycerides influence HRV (p < 0.05). the results suggest that ESR1 variants have no effect on cardiorespiratory and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in healthy women.
Keywords estrogen receptor-alpha gene polymorphisms
heart rate variability
aerobic capacity
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number CNPq: 370448/2007-3
FAPESP: 2006/56788-1
Date 2012-10-01
Published in International Journal of Molecular Sciences. Basel: Mdpi Ag, v. 13, n. 10, p. 13691-13703, 2012.
ISSN 1422-0067 (Sherpa/Romeo, impact factor)
Publisher Mdpi Ag
Extent 13691-13703
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000310677800086

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