Evaluation of Ultrasound-Assisted Thrombolysis Using Custom Liposomes in a Model of Retinal Vein Occlusion

Evaluation of Ultrasound-Assisted Thrombolysis Using Custom Liposomes in a Model of Retinal Vein Occlusion

Author Abdallah, Walid F. Google Scholar
Patel, Hitenkumar Google Scholar
Grant, Edward G. Google Scholar
Diniz, Bruno Autor UNIFESP Google Scholar
Chader, Gerald J. Google Scholar
Humayun, Mark S. Google Scholar
Institution Doheny Eye Inst
Zagazig Univ
Univ So Calif
Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE. To study the potential efficacy of ultrasound (US) assisted by custom liposome (CLP) destruction as an innovative thrombolytic tool for the treatment of retinal vein occlusion (RVO).METHODS. Experimental RVO was induced in the right eyes of 40 rabbits using laser photothrombosis; the US experiment took place 48 hours later. Rabbits were randomly divided into four equal groups: US+CLP group, US+saline group, CLP+sham US group, and no treatment group. the latter three groups acted as controls. Fundus fluorescein angiography and Doppler US were used to evaluate retinal blood flow.RESULTS. CLP-assisted US thrombolysis resulted in restoration of flow in seven rabbits (70%). None of the control groups showed significant restoration of retinal venous blood flow.CONCLUSIONS. US-assisted thrombolysis using liposomes resulted in a statistically significant reperfusion of retinal vessels in the rabbit experimental model of RVO. This approach might be promising in the treatment of RVO in humans. Further studies are needed to evaluate this approach in patients with RVO. Ultrasound assisted thrombolysis can be an innovative tool in management of retinal vein occlusion. (Invest Ophthalmol Vis Sci. 2012;53:6920-6927) DOI:10.1167/iovs.12-10389
Language English
Sponsor National Eye Institute
Grant number National Eye Institute: EY03040
Date 2012-10-01
Published in Investigative Ophthalmology & Visual Science. Rockville: Assoc Research Vision Ophthalmology Inc, v. 53, n. 11, p. 6920-6927, 2012.
ISSN 0146-0404 (Sherpa/Romeo, impact factor)
Publisher Assoc Research Vision Ophthalmology Inc
Extent 6920-6927
Origin http://dx.doi.org/10.1167/iovs.12-10389
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000310589900025
URI http://repositorio.unifesp.br/handle/11600/35321

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