Impairment of Sexual Function in Rats with Epilepsy

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dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.contributor.author Alvarenga, Tathiana A. [UNIFESP]
dc.contributor.author Scorza, Fulvio A. [UNIFESP]
dc.contributor.author Matos, Gabriela [UNIFESP]
dc.contributor.author Sonoda, Eliza Y. [UNIFESP]
dc.contributor.author Hirotsu, Camila [UNIFESP]
dc.contributor.author Cavalheiro, Esper A. [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:41Z
dc.date.available 2016-01-24T14:27:41Z
dc.date.issued 2012-09-01
dc.identifier http://dx.doi.org/10.1111/j.1743-6109.2012.02792.x
dc.identifier.citation Journal of Sexual Medicine. Hoboken: Wiley-Blackwell, v. 9, n. 9, p. 2266-2272, 2012.
dc.identifier.issn 1743-6095
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35259
dc.description.abstract Introduction. Epilepsy is a chronic disease that affects men and women of all ages, with different levels of severity. Many individuals with epilepsy also suffer from impairments in sexual function. However, it is difficult to differentiate between the impact of the disease and the impact of antiepileptic drugs on sexual function in human subjects. Aims. To evaluate sexual behavior in adult male rats submitted to chronic pilocarpine-induced epilepsy. Methods. First, non-epileptic rats were exposed to nine training sessions to acquire sexual experience, and their baseline sexual performance was evaluated. Then, the same rats were given pilocarpine to induce status epilepticus followed by chronic epilepsy. Once the animals had developed spontaneous recurrent seizures, their sexual behavior was evaluated during three sessions. Main Outcome Measures. Examine changes in latencies to first mount, intromission, and ejaculation, and the total number of mounts, intromissions, and ejaculations. Results. All outcome measures related to sexual motivation and sexual performance were markedly impaired during chronic epilepsy compared with the baseline and the control group. Conclusion. These findings will aid in understanding the interaction between sexual behavior and epilepsy, as well as encouraging further experimental studies in human patients with epilepsy suffering from sexual dysfunction. Andersen ML, Alvarenga TA, Scorza FA, Matos G, Sonoda EY, Hirotsu C, Cavalheiro EA, and Tufik S. Impairment of sexual function in rats with epilepsy. J Sex Med 2012;9:22662272. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 2266-2272
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Sexual Medicine
dc.rights Acesso restrito
dc.subject Sexual Behavior en
dc.subject Epilepsy en
dc.subject Erection en
dc.subject Seizure en
dc.subject Pilocarpine en
dc.subject Erectile Dysfunction en
dc.subject Animal Models of Impaired Sexual Function en
dc.title Impairment of Sexual Function in Rats with Epilepsy en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Neurol Expt, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Neurol Expt, BR-04024002 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 98/14303-3
dc.description.sponsorshipID FAPESP: 09/01030-5
dc.description.sponsorshipID FAPESP: 11/12325-6
dc.description.sponsorshipID FAPESP: 10/50129-1
dc.description.sponsorshipID FAPESP: 09/14206-4
dc.identifier.doi 10.1111/j.1743-6109.2012.02792.x
dc.description.source Web of Science
dc.identifier.wos WOS:000308391900009



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