Impairment of Sexual Function in Rats with Epilepsy

Impairment of Sexual Function in Rats with Epilepsy

Author Andersen, Monica L. Autor UNIFESP Google Scholar
Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Matos, Gabriela Autor UNIFESP Google Scholar
Sonoda, Eliza Y. Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction. Epilepsy is a chronic disease that affects men and women of all ages, with different levels of severity. Many individuals with epilepsy also suffer from impairments in sexual function. However, it is difficult to differentiate between the impact of the disease and the impact of antiepileptic drugs on sexual function in human subjects. Aims. To evaluate sexual behavior in adult male rats submitted to chronic pilocarpine-induced epilepsy. Methods. First, non-epileptic rats were exposed to nine training sessions to acquire sexual experience, and their baseline sexual performance was evaluated. Then, the same rats were given pilocarpine to induce status epilepticus followed by chronic epilepsy. Once the animals had developed spontaneous recurrent seizures, their sexual behavior was evaluated during three sessions. Main Outcome Measures. Examine changes in latencies to first mount, intromission, and ejaculation, and the total number of mounts, intromissions, and ejaculations. Results. All outcome measures related to sexual motivation and sexual performance were markedly impaired during chronic epilepsy compared with the baseline and the control group. Conclusion. These findings will aid in understanding the interaction between sexual behavior and epilepsy, as well as encouraging further experimental studies in human patients with epilepsy suffering from sexual dysfunction. Andersen ML, Alvarenga TA, Scorza FA, Matos G, Sonoda EY, Hirotsu C, Cavalheiro EA, and Tufik S. Impairment of sexual function in rats with epilepsy. J Sex Med 2012;9:22662272.
Keywords Sexual Behavior
Erectile Dysfunction
Animal Models of Impaired Sexual Function
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 98/14303-3
FAPESP: 09/01030-5
FAPESP: 11/12325-6
FAPESP: 10/50129-1
FAPESP: 09/14206-4
Date 2012-09-01
Published in Journal of Sexual Medicine. Hoboken: Wiley-Blackwell, v. 9, n. 9, p. 2266-2272, 2012.
ISSN 1743-6095 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2266-2272
Access rights Closed access
Type Article
Web of Science ID WOS:000308391900009

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