Acute and chronic ethanol differentially modify the emotional significance of a novel environment: implications for addiction

Acute and chronic ethanol differentially modify the emotional significance of a novel environment: implications for addiction

Author Fukushiro, Daniela Fukue Autor UNIFESP Google Scholar
Josino, Fabiana de Souza Autor UNIFESP Google Scholar
Saito, Luis Paulo Autor UNIFESP Google Scholar
Berro, Laís Fernanda Autor UNIFESP Google Scholar
Morgado, Fiorella Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Using open-field behaviour as an experimental paradigm, we demonstrated a complex interaction between the rewarding/stimulating effects and the anxiogenic/stressful effects of both novelty and acute or chronic amphetamine in mice. As a consequence of this interaction, acute amphetamine-induced hyperlocomotion was inhibited, whereas the expression of its sensitization was facilitated in a novel environment. in the present study, we aimed to investigate the interactions between exposure to a novel environment and the acute and chronic effects of ethanol (Eth), a drug of abuse known to produce anxiolytic-like behaviour in mice. Previously habituated and non-habituated male Swiss mice (3 months old) were tested in an open field after receiving an acute injection of Eth or following repeated treatment with Eth. Acute Eth administration increased locomotion with a greater magnitude in mice exposed to the apparatus for the first time, and this was thought to be related to the attenuation of the stressful effects of novelty produced by the anxiolytic-like effect of acute Eth, leading to a subsequent prevalence of its stimulant effects. However, locomotor sensitization produced by repeated Eth administration was expressed only in the previously explored environment. This result might be related to the well-known tolerance of Eth-induced anxiolytic-like behaviour following repeated treatment, which would restore the anxiogenic effect of novelty. Our data suggest that a complex and plastic interaction between the emotional and motivational properties of novelty and drugs of abuse can critically modify the behavioural expression of addiction-related mechanisms.
Keywords Behavioural sensitization
ethanol
habituation
hyperlocomotion
novelty
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundo de Apoio ao Docente e Aluno (FADA)
Associacao Fundo de Pesquisa em Psicobiologia (AFIP)
Date 2012-09-01
Published in International Journal of Neuropsychopharmacology. New York: Cambridge Univ Press, v. 15, n. 8, p. 1109-1120, 2012.
ISSN 1461-1457 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 1109-1120
Origin http://dx.doi.org/10.1017/S1461145711001283
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000307188000009
URI http://repositorio.unifesp.br/handle/11600/35190

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