PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility

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dc.contributor.author Matos, Gabriela [UNIFESP]
dc.contributor.author Scorza, Fulvio A. [UNIFESP]
dc.contributor.author Cavalheiro, Esper A. [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:32Z
dc.date.available 2016-01-24T14:27:32Z
dc.date.issued 2012-08-01
dc.identifier http://dx.doi.org/10.1111/j.1743-6109.2012.02780.x
dc.identifier.citation Journal of Sexual Medicine. Hoboken: Wiley-Blackwell, v. 9, n. 8, p. 2111-2121, 2012.
dc.identifier.issn 1743-6095
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35155
dc.description.abstract Introduction. There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group. Aim. the main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility. Methods. All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. Main Outcome Measures. the main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility. Results. Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction. Conclusions. Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. in addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic. Matos G, Scorza FA, Cavalheiro EA, Tufik S, and Andersen ML. PDEI-5 for erectile dysfunction: A potential role in seizure susceptibility. J Sex Med 2012;9:21112121. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorship Instituto Nacional de Neurociencia Translacional (INNT)
dc.description.sponsorship Cooperacao Interinstitucional de Apoio a Pesquisas sobre o Cerebro (CInAPCe)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 2111-2121
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Sexual Medicine
dc.rights Acesso restrito
dc.subject PDEI-5 en
dc.subject Erectile Dysfunction en
dc.subject Complications of PDEI-5 en
dc.subject Seizure en
dc.subject Human en
dc.subject Animal Models en
dc.title PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility en
dc.type Resenha
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 98/14303-3
dc.description.sponsorshipID FAPESP: 2010/15110-8
dc.identifier.doi 10.1111/j.1743-6109.2012.02780.x
dc.description.source Web of Science
dc.identifier.wos WOS:000307017100016



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