PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility

PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility

Author Matos, Gabriela Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction. There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group. Aim. the main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility. Methods. All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. Main Outcome Measures. the main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility. Results. Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction. Conclusions. Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. in addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic. Matos G, Scorza FA, Cavalheiro EA, Tufik S, and Andersen ML. PDEI-5 for erectile dysfunction: A potential role in seizure susceptibility. J Sex Med 2012;9:21112121.
Keywords PDEI-5
Erectile Dysfunction
Complications of PDEI-5
Seizure
Human
Animal Models
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Instituto Nacional de Neurociencia Translacional (INNT)
Cooperacao Interinstitucional de Apoio a Pesquisas sobre o Cerebro (CInAPCe)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 98/14303-3
FAPESP: 2010/15110-8
Date 2012-08-01
Published in Journal of Sexual Medicine. Hoboken: Wiley-Blackwell, v. 9, n. 8, p. 2111-2121, 2012.
ISSN 1743-6095 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2111-2121
Origin http://dx.doi.org/10.1111/j.1743-6109.2012.02780.x
Access rights Closed access
Type Review
Web of Science ID WOS:000307017100016
URI http://repositorio.unifesp.br/handle/11600/35155

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