Individual differences are critical in determining modafinil-induced behavioral sensitization and cross-sensitization with methamphetamine in mice

Individual differences are critical in determining modafinil-induced behavioral sensitization and cross-sensitization with methamphetamine in mice

Author Soeiro, Aline da Costa Autor UNIFESP Google Scholar
Moreira, Karin Di Monteiro Autor UNIFESP Google Scholar
Abrahao, Karina Possa Autor UNIFESP Google Scholar
Hartmann Quadros, Isabel Marian Autor UNIFESP Google Scholar
Menezes Oliveira, Maria Gabriela Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Modafinil is a non-amphetaminic psychostimulant used therapeutically for sleep and psychiatric disorders. However, some studies indicate that modafinil can have addictive properties. the present study examined whether modafinil can produce behavioral sensitization in mice, an experience and drug-dependent behavioral adaptation, and if individual differences play a role in this process. We further tested context-related factors and cross-sensitization between modafinil and methamphetamine. Important individual differences in the behavioral sensitization of Swiss Albino mice were observed after repeated administration of 50 mg/kg modafinil (Experiment 1), or 1 mg/kg methamphetamine (Experiment 2). Only mice classified as sensitized subgroup developed clear behavioral sensitization to the drugs. After a withdrawal period, mice received challenges of modafinil (Experiment 1), or methamphetamine (Experiment 2) and locomotor activity was evaluated in the activity cages (previous context) and in the open field arena (new context) in order to evaluate the context dependency of behavioral sensitization. the expression of sensitization to modafinil, but not to methamphetamine, was affected by contextual testing conditions, since modafinil-sensitized mice only expressed sensitization in the activity cage, but not in the open field. Subsequently, locomotor cross-sensitization between methamphetamine and modafinil was assessed by challenging modafinil-pretreated mice with 1 mg/kg methamphetamine (Experiment 1), and methamphetamine-pretreated mice with 50 mg/kg modafinil (Experiment 2). We observed a symmetrical cross-sensitization between the drugs only in those mice that were classified as sensitized subgroup. Our findings indicate that repeated exposure to modafinil induces behavioral sensitization only in some animals by similar neurobiological, but not contextual, mechanisms to those. of methamphetamine. (c) 2012 Elsevier B.V. All rights reserved.
Keywords Locomotor sensitization
Individual variability
Amphetamines
Drugs of abuse
Locomotor activity
Mice
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-08-01
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 233, n. 2, p. 367-374, 2012.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 367-374
Origin http://dx.doi.org/10.1016/j.bbr.2012.05.023
Access rights Closed access
Type Article
Web of Science ID WOS:000307368400017
URI http://repositorio.unifesp.br/handle/11600/35131

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