Gender-related differences in the burden of non-motor symptoms in Parkinson's disease

Gender-related differences in the burden of non-motor symptoms in Parkinson's disease

Author Martinez-Martin, Pablo Google Scholar
Pecurariu, Cristian Falup Google Scholar
Odin, Per Google Scholar
van Hilten, Jacobus J. Google Scholar
Antonini, Angelo Google Scholar
Rojo-Abuin, Jose M. Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Trenkwalder, Claudia Google Scholar
Aarsland, Dag Google Scholar
Brooks, David J. Google Scholar
Chaudhuri, Kallol Ray Google Scholar
Institution Reina Sofia Fdn
CIBERNED Carlos III Inst Hlth
Transylvania Univ
Univ Lund Hosp
Cent Hosp
Leiden Univ
IRCCS San Camillo
Spanish Council Sci Res
Universidade Federal de São Paulo (UNIFESP)
Paracelsus Elena Hosp
Karolinska Inst
Stavanger Univ Hosp
Univ London Imperial Coll Sci Technol & Med
Kings Coll Hosp
Univ Hosp Lewisham
Abstract Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD) patients may have important implications for their management and prognosis. Gender is a basic epidemiological variable that could influence such expression. the present study evaluated the prevalence and severity of NMS by gender in an international sample of 951 PD patients, 62.63% males, using the non-motor symptoms scale (NMSS). Assessments for motor impairment and complications, global severity, and health state were also applied. All disease stages were included. No significant gender differences were found for demographic and clinical characteristics. for the entire sample, the most prevalent symptoms were Nocturia (64.88%) and Fatigue (62.78%) and the most prevalent affected domains were Sleep/Fatigue (84.02%) and Miscellaneous (82.44%). Fatigue, feelings of nervousness, feelings of sadness, constipation, restless legs, and pain were more common and severe in women. On the contrary, daytime sleepiness, dribbling saliva, interest in sex, and problems having sex were more prevalent and severe in men. Regarding the NMSS domains, Mood/Apathy and Miscellaneous problems (pain, loss of taste or smell, weight change, and excessive sweating) were predominantly affected in women and Sexual dysfunction in men. No other significant differences by gender were observed. To conclude, in this study significant differences between men and women in prevalence and severity of fatigue, mood, sexual and digestive problems, pain, restless legs, and daytime sleepiness were found. Gender-related patterns of NMS involvement may be relevant for clinical trials in PD.
Keywords Parkinson's disease
Non-motor symptoms
Language English
Date 2012-08-01
Published in Journal of Neurology. Heidelberg: Springer Heidelberg, v. 259, n. 8, p. 1639-1647, 2012.
ISSN 0340-5354 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1639-1647
Access rights Closed access
Type Article
Web of Science ID WOS:000307267300016

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